195281

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 848563..849077 Replicon chromosome
Accession NZ_CP071094
Organism Fusobacterium polymorphum strain THCT15E1

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag JY397_RS04325 Protein ID WP_098978559.1
Coordinates 848820..849077 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag JY397_RS04320 Protein ID WP_098978558.1
Coordinates 848563..848820 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY397_RS04300 (JY397_04295) 843695..845788 + 2094 WP_220303372.1 outer membrane protein assembly factor -
JY397_RS04305 (JY397_04300) 845828..846301 + 474 WP_005894577.1 OmpH family outer membrane protein -
JY397_RS04310 (JY397_04305) 846327..847325 + 999 WP_220303373.1 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -
JY397_RS04315 (JY397_04310) 847369..848436 + 1068 WP_005901428.1 glycerophosphodiester phosphodiesterase -
JY397_RS04320 (JY397_04315) 848563..848820 + 258 WP_098978558.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JY397_RS04325 (JY397_04320) 848820..849077 + 258 WP_098978559.1 Txe/YoeB family addiction module toxin Toxin
JY397_RS04330 (JY397_04325) 849194..850270 + 1077 WP_023037955.1 DHH family phosphoesterase -
JY397_RS04335 (JY397_04330) 850502..851239 + 738 WP_023037954.1 tRNA pseudouridine(38-40) synthase TruA -
JY397_RS04340 (JY397_04335) 851362..851715 + 354 WP_023037953.1 hypothetical protein -
JY397_RS04345 (JY397_04340) 851810..852376 + 567 WP_023037952.1 hypothetical protein -
JY397_RS04350 (JY397_04345) 852578..852910 + 333 WP_023037951.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10144.74 Da        Isoelectric Point: 9.7287

>T195281 WP_098978559.1 NZ_CP071094:848820-849077 [Fusobacterium polymorphum]
MLLTWTDFAWKQYEELQEKDKRLIKKINILIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKVSDSQIIIVAC
ANHYK

Download         Length: 258 bp

>T195281 NZ_CP094479:1915149-1915251 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10122.48 Da        Isoelectric Point: 4.7022

>AT195281 WP_098978558.1 NZ_CP071094:848563-848820 [Fusobacterium polymorphum]
MIATNYSEVRNNLKAYCDKATKDYEIIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQKLVESIKEVEKGNVKEHD
LIEVD

Download         Length: 258 bp

>AT195281 NZ_CP094479:c1915258-1915113 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References