Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-RelB |
| Location | 581838..582165 | Replicon | chromosome |
| Accession | NZ_CP071094 | ||
| Organism | Fusobacterium polymorphum strain THCT15E1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | JY397_RS03085 | Protein ID | WP_141757152.1 |
| Coordinates | 582037..582165 (+) | Length | 43 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | JY397_RS03080 | Protein ID | WP_238983046.1 |
| Coordinates | 581838..582035 (+) | Length | 66 a.a. |
Genomic Context
Location: 578236..579132 (897 bp)
Type: Others
Protein ID: WP_220303266.1
Type: Others
Protein ID: WP_220303266.1
Location: 579134..580426 (1293 bp)
Type: Others
Protein ID: WP_220303267.1
Type: Others
Protein ID: WP_220303267.1
Location: 580404..581264 (861 bp)
Type: Others
Protein ID: WP_070766926.1
Type: Others
Protein ID: WP_070766926.1
Location: 581257..581766 (510 bp)
Type: Others
Protein ID: WP_032890435.1
Type: Others
Protein ID: WP_032890435.1
Location: 581838..582035 (198 bp)
Type: Antitoxin
Protein ID: WP_238983046.1
Type: Antitoxin
Protein ID: WP_238983046.1
Location: 582037..582165 (129 bp)
Type: Toxin
Protein ID: WP_141757152.1
Type: Toxin
Protein ID: WP_141757152.1
Location: 582167..582931 (765 bp)
Type: Others
Protein ID: WP_008694117.1
Type: Others
Protein ID: WP_008694117.1
Location: 584489..585178 (690 bp)
Type: Others
Protein ID: WP_220303268.1
Type: Others
Protein ID: WP_220303268.1
Location: 585827..586978 (1152 bp)
Type: Others
Protein ID: Protein_600
Type: Others
Protein ID: Protein_600
Location: 583290..583796 (507 bp)
Type: Others
Protein ID: WP_060496643.1
Type: Others
Protein ID: WP_060496643.1
Location: 583841..584344 (504 bp)
Type: Others
Protein ID: WP_060496644.1
Type: Others
Protein ID: WP_060496644.1
Location: 585175..585726 (552 bp)
Type: Others
Protein ID: WP_220303269.1
Type: Others
Protein ID: WP_220303269.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JY397_RS03060 (JY397_03055) | 578236..579132 | + | 897 | WP_220303266.1 | quinolinate synthase NadA | - |
| JY397_RS03065 (JY397_03060) | 579134..580426 | + | 1293 | WP_220303267.1 | L-aspartate oxidase | - |
| JY397_RS03070 (JY397_03065) | 580404..581264 | + | 861 | WP_070766926.1 | carboxylating nicotinate-nucleotide diphosphorylase | - |
| JY397_RS03075 (JY397_03070) | 581257..581766 | + | 510 | WP_032890435.1 | transcription repressor NadR | - |
| JY397_RS03080 (JY397_03075) | 581838..582035 | + | 198 | WP_238983046.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| JY397_RS03085 (JY397_03080) | 582037..582165 | + | 129 | WP_141757152.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| JY397_RS03090 (JY397_03085) | 582167..582931 | + | 765 | WP_008694117.1 | class I SAM-dependent methyltransferase | - |
| JY397_RS03095 (JY397_03090) | 583290..583796 | - | 507 | WP_060496643.1 | AAA family ATPase | - |
| JY397_RS03100 (JY397_03095) | 583841..584344 | - | 504 | WP_060496644.1 | YfbM family protein | - |
| JY397_RS03105 (JY397_03100) | 584489..585178 | + | 690 | WP_220303268.1 | DUF554 domain-containing protein | - |
| JY397_RS03110 (JY397_03105) | 585175..585726 | - | 552 | WP_220303269.1 | DUF1877 family protein | - |
| JY397_RS03115 (JY397_03110) | 585827..586978 | + | 1152 | Protein_600 | IS200/IS605 family element RNA-guided endonuclease TnpB | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 585827..585979 | 152 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 43 a.a. Molecular weight: 4990.10 Da Isoelectric Point: 10.8454
>T195280 WP_141757152.1 NZ_CP071094:582037-582165 [Fusobacterium polymorphum]
MYEIKTTTKFEKDLKLMKKRGYNLKLLKEVINMLSKGAKSRL
MYEIKTTTKFEKDLKLMKKRGYNLKLLKEVINMLSKGAKSRL
Download Length: 129 bp
>T195280 NZ_CP071094:582037-582165 [Fusobacterium polymorphum]
ATGTATGAAATTAAGACCACTACTAAATTTGAAAAAGACTTAAAATTAATGAAAAAAAGAGGATATAATTTAAAATTATT
AAAAGAGGTAATTAATATGTTATCTAAAGGAGCTAAAAGCAGATTATAA
ATGTATGAAATTAAGACCACTACTAAATTTGAAAAAGACTTAAAATTAATGAAAAAAAGAGGATATAATTTAAAATTATT
AAAAGAGGTAATTAATATGTTATCTAAAGGAGCTAAAAGCAGATTATAA
Antitoxin
Download Length: 66 a.a. Molecular weight: 7300.49 Da Isoelectric Point: 5.0000
>AT195280 WP_238983046.1 NZ_CP071094:581838-582035 [Fusobacterium polymorphum]
MGLNISVAINLFLKKCINENGMPFDLKIPNKKTIEAMEGTNKILNGDIERKSYKNADELFEDLGV
MGLNISVAINLFLKKCINENGMPFDLKIPNKKTIEAMEGTNKILNGDIERKSYKNADELFEDLGV
Download Length: 198 bp
>AT195280 NZ_CP071094:581838-582035 [Fusobacterium polymorphum]
TTGGGACTTAATATATCAGTTGCAATAAATTTATTTCTAAAAAAATGTATAAATGAAAATGGGATGCCATTTGATTTAAA
AATTCCAAATAAAAAAACAATAGAAGCAATGGAAGGAACTAACAAAATATTAAATGGAGATATAGAAAGAAAGTCATATA
AAAATGCTGATGAGTTATTTGAAGATTTAGGTGTGTAA
TTGGGACTTAATATATCAGTTGCAATAAATTTATTTCTAAAAAAATGTATAAATGAAAATGGGATGCCATTTGATTTAAA
AATTCCAAATAAAAAAACAATAGAAGCAATGGAAGGAACTAACAAAATATTAAATGGAGATATAGAAAGAAAGTCATATA
AAAATGCTGATGAGTTATTTGAAGATTTAGGTGTGTAA