Detailed information of TA system TA195280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 581838..582165
• Replicon: chromosome
• Accession: NZ_CP071094
• Organism: Fusobacterium polymorphum strain THCT15E1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JY397_RS03085
• Protein ID: WP_141757152.1
• Coordinates: 582037..582165 (+)
• Length: 43 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JY397_RS03080
• Protein ID: WP_238983046.1
• Coordinates: 581838..582035 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JY397_RS03060 (JY397_03055)	578236..579132	+	897	WP_220303266.1	quinolinate synthase NadA	-
JY397_RS03065 (JY397_03060)	579134..580426	+	1293	WP_220303267.1	L-aspartate oxidase	-
JY397_RS03070 (JY397_03065)	580404..581264	+	861	WP_070766926.1	carboxylating nicotinate-nucleotide diphosphorylase	-
JY397_RS03075 (JY397_03070)	581257..581766	+	510	WP_032890435.1	transcription repressor NadR	-
JY397_RS03080 (JY397_03075)	581838..582035	+	198	WP_238983046.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JY397_RS03085 (JY397_03080)	582037..582165	+	129	WP_141757152.1	type II toxin-antitoxin system YafQ family toxin	Toxin
JY397_RS03090 (JY397_03085)	582167..582931	+	765	WP_008694117.1	class I SAM-dependent methyltransferase	-
JY397_RS03095 (JY397_03090)	583290..583796	-	507	WP_060496643.1	AAA family ATPase	-
JY397_RS03100 (JY397_03095)	583841..584344	-	504	WP_060496644.1	YfbM family protein	-
JY397_RS03105 (JY397_03100)	584489..585178	+	690	WP_220303268.1	DUF554 domain-containing protein	-
JY397_RS03110 (JY397_03105)	585175..585726	-	552	WP_220303269.1	DUF1877 family protein	-
JY397_RS03115 (JY397_03110)	585827..586978	+	1152	Protein_600	IS200/IS605 family element RNA-guided endonuclease TnpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	585827..585979	152

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-37)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4990.10 Da
• Isoelectric Point: 10.8454

>T195280 WP_141757152.1 NZ_CP071094:582037-582165 [Fusobacterium polymorphum]
MYEIKTTTKFEKDLKLMKKRGYNLKLLKEVINMLSKGAKSRL

Nucleotide

• Length: 129 bp

>T195280 NZ_CP071094:582037-582165 [Fusobacterium polymorphum]
ATGTATGAAATTAAGACCACTACTAAATTTGAAAAAGACTTAAAATTAATGAAAAAAAGAGGATATAATTTAAAATTATT
AAAAGAGGTAATTAATATGTTATCTAAAGGAGCTAAAAGCAGATTATAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7300.49 Da
• Isoelectric Point: 5.0000

>AT195280 WP_238983046.1 NZ_CP071094:581838-582035 [Fusobacterium polymorphum]
MGLNISVAINLFLKKCINENGMPFDLKIPNKKTIEAMEGTNKILNGDIERKSYKNADELFEDLGV

Nucleotide

• Length: 198 bp

>AT195280 NZ_CP071094:581838-582035 [Fusobacterium polymorphum]
TTGGGACTTAATATATCAGTTGCAATAAATTTATTTCTAAAAAAATGTATAAATGAAAATGGGATGCCATTTGATTTAAA
AATTCCAAATAAAAAAACAATAGAAGCAATGGAAGGAACTAACAAAATATTAAATGGAGATATAGAAAGAAAGTCATATA
AAAATGCTGATGAGTTATTTGAAGATTTAGGTGTGTAA