Detailed information of TA system TA195279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 506888..507376
• Replicon: chromosome
• Accession: NZ_CP071094
• Organism: Fusobacterium polymorphum strain THCT15E1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JY397_RS02715
• Protein ID: WP_220303255.1
• Coordinates: 506888..507151 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JY397_RS02720
• Protein ID: WP_088389127.1
• Coordinates: 507152..507376 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JY397_RS02680 (JY397_02675)	502008..502403	-	396	WP_220303253.1	adhesion protein FadA	-
JY397_RS02685 (JY397_02680)	502558..503061	-	504	WP_005901036.1	hypothetical protein	-
JY397_RS02690 (JY397_02685)	503250..503717	+	468	WP_005901035.1	helix-turn-helix domain-containing protein	-
JY397_RS02695 (JY397_02690)	503668..504093	+	426	WP_023038164.1	ImmA/IrrE family metallo-endopeptidase	-
JY397_RS02700 (JY397_02695)	504126..504665	-	540	WP_032835187.1	TlpA disulfide reductase family protein	-
JY397_RS02705 (JY397_02700)	504687..506144	-	1458	WP_208895454.1	HD domain-containing protein	-
JY397_RS02710 (JY397_02705)	506205..506804	-	600	WP_220303254.1	hypothetical protein	-
JY397_RS02715 (JY397_02710)	506888..507151	-	264	WP_220303255.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JY397_RS02720 (JY397_02715)	507152..507376	-	225	WP_088389127.1	DUF6290 family protein	Antitoxin
JY397_RS02725 (JY397_02720)	507446..508207	-	762	Protein_522	alanine:cation symporter family protein	-
JY397_RS02730 (JY397_02725)	508327..509574	-	1248	WP_220303256.1	RNA-guided endonuclease TnpB family protein	-
JY397_RS02735 (JY397_02730)	510158..510745	-	588	Protein_524	alanine:cation symporter family protein	-
JY397_RS02740 (JY397_02735)	510871..512346	-	1476	WP_088337737.1	cobyric acid synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-85)

Antitoxin

• Protein of unknown function DUF6290 (1-72)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10559.48 Da
• Isoelectric Point: 10.1172

>T195279 WP_220303255.1 NZ_CP071094:c507151-506888 [Fusobacterium polymorphum]
MYKVYFDKKVEKDFKKLDKKVLKLILDWIENNLENIEEPRSKGKALVGNLKDYWRYRIGDYRLITKIDDGKLLIIALELK
HRKEAYK

Nucleotide

• Length: 264 bp

>T195279 NZ_CP094479:862861-863271 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGTTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8686.02 Da
• Isoelectric Point: 5.8834

>AT195279 WP_088389127.1 NZ_CP071094:c507376-507152 [Fusobacterium polymorphum]
MSNITLRLTDEEREILNSVAHLYGDKLSTAIKTILFEKIEEDYNLKIVKDFEKREKENKVELVSLSDFRKKLGV

Nucleotide

• Length: 225 bp

>AT195279 NZ_CP094479:862614-862880 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA