195278

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 696723..697237 Replicon chromosome
Accession NZ_CP071093
Organism Fusobacterium vincentii strain THCT14A3

Toxin (Protein)


Gene name relB Uniprot ID A0A806U886
Locus tag JY399_RS03190 Protein ID WP_005911996.1
Coordinates 696723..696980 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829KW90
Locus tag JY399_RS03195 Protein ID WP_005911998.1
Coordinates 696980..697237 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY399_RS03170 (JY399_03170) 692464..693771 - 1308 WP_220278828.1 electron transport complex subunit RsxC -
JY399_RS03175 (JY399_03175) 693845..694420 - 576 WP_008800340.1 aminoacyl-tRNA hydrolase -
JY399_RS03180 (JY399_03180) 694562..695299 - 738 WP_204679808.1 tRNA pseudouridine(38-40) synthase TruA -
JY399_RS03185 (JY399_03185) 695531..696607 - 1077 WP_008803535.1 DHH family phosphoesterase -
JY399_RS03190 (JY399_03190) 696723..696980 - 258 WP_005911996.1 Txe/YoeB family addiction module toxin Toxin
JY399_RS03195 (JY399_03195) 696980..697237 - 258 WP_005911998.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JY399_RS03200 (JY399_03200) 697356..698426 - 1071 WP_220278829.1 glycerophosphodiester phosphodiesterase -
JY399_RS03205 (JY399_03205) 698470..699468 - 999 WP_220278830.1 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -
JY399_RS03210 (JY399_03210) 699491..699964 - 474 WP_005892890.1 OmpH family outer membrane protein -
JY399_RS03215 (JY399_03215) 700005..702098 - 2094 WP_220278831.1 outer membrane protein assembly factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10207.79 Da        Isoelectric Point: 9.3654

>T195278 WP_005911996.1 NZ_CP071093:c696980-696723 [Fusobacterium vincentii]
MLLTWTDFAWEQYEELQEKDKRLVKKINILIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDYKNRLVYKISDTQIIIVAC
ANHYK

Download         Length: 258 bp

>T195278 NZ_CP094479:369217-369564 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10126.43 Da        Isoelectric Point: 4.7022

>AT195278 WP_005911998.1 NZ_CP071093:c697237-696980 [Fusobacterium vincentii]
MIATNYSEVRNNLKTYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQKLVESIKEVEKGNVKEHD
LVEVD

Download         Length: 258 bp

>AT195278 NZ_CP094479:369564-369863 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806U886

Antitoxin

Source ID Structure
AlphaFold DB A0A829KW90

References