Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1426089..1426603 Replicon chromosome
Accession NZ_CP071092
Organism Fusobacterium hwasookii strain THCT14E2

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag JY400_RS06965 Protein ID WP_029494261.1
Coordinates 1426346..1426603 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID U7TQU0
Locus tag JY400_RS06960 Protein ID WP_005919458.1
Coordinates 1426089..1426346 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY400_RS06940 (JY400_06940) 1421223..1423316 + 2094 WP_029490887.1 outer membrane protein assembly factor -
JY400_RS06945 (JY400_06945) 1423356..1423829 + 474 WP_029490886.1 OmpH family outer membrane protein -
JY400_RS06950 (JY400_06950) 1423854..1424852 + 999 WP_220280479.1 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -
JY400_RS06955 (JY400_06955) 1424896..1425969 + 1074 WP_029490884.1 glycerophosphodiester phosphodiesterase -
JY400_RS06960 (JY400_06960) 1426089..1426346 + 258 WP_005919458.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JY400_RS06965 (JY400_06965) 1426346..1426603 + 258 WP_029494261.1 Txe/YoeB family addiction module toxin Toxin
JY400_RS06970 (JY400_06970) 1426720..1427796 + 1077 WP_029490883.1 DHH family phosphoesterase -
JY400_RS06975 (JY400_06975) 1428029..1428766 + 738 WP_029494262.1 tRNA pseudouridine(38-40) synthase TruA -
JY400_RS06980 (JY400_06980) 1428974..1429549 + 576 WP_029490878.1 aminoacyl-tRNA hydrolase -
JY400_RS06985 (JY400_06985) 1429624..1430931 + 1308 WP_005919435.1 electron transport complex subunit RsxC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10060.57 Da        Isoelectric Point: 9.7287

>T195277 WP_029494261.1 NZ_CP071092:1426346-1426603 [Fusobacterium hwasookii]
MLLTWTDFASKQYEELQEKDKRLIKKINILIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKVSDNQITIVAC
ANHYK

Download         Length: 258 bp

>T195277 NZ_CP094479:343247-343615 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10110.43 Da        Isoelectric Point: 4.7022

>AT195277 WP_005919458.1 NZ_CP071092:1426089-1426346 [Fusobacterium hwasookii]
MIATNYSEVRNNLKAYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQKLVESIKEVEKGNVKEHD
LIEVD

Download         Length: 258 bp

>AT195277 NZ_CP094479:343029-343250 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S2ZLE4

References