Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 5189891..5191572 | Replicon | chromosome |
| Accession | NZ_CP071086 | ||
| Organism | Klebsiella pneumoniae strain 3347689I | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A483YLF8 |
| Locus tag | JY394_RS25785 | Protein ID | WP_019724882.1 |
| Coordinates | 5189891..5190808 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A6TH05 |
| Locus tag | JY394_RS25790 | Protein ID | WP_004177809.1 |
| Coordinates | 5190814..5191572 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JY394_RS25765 (JY394_25765) | 5185197..5186717 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| JY394_RS25770 (JY394_25770) | 5186714..5187712 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| JY394_RS25775 (JY394_25775) | 5187743..5188684 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| JY394_RS25780 (JY394_25780) | 5188759..5189766 | + | 1008 | WP_015959270.1 | carbohydrate kinase family protein | - |
| JY394_RS25785 (JY394_25785) | 5189891..5190808 | - | 918 | WP_019724882.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| JY394_RS25790 (JY394_25790) | 5190814..5191572 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| JY394_RS25795 (JY394_25795) | 5191658..5192386 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
| JY394_RS25800 (JY394_25800) | 5192659..5194806 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
| JY394_RS25805 (JY394_25805) | 5195036..5195722 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34653.14 Da Isoelectric Point: 5.4707
>T195274 WP_019724882.1 NZ_CP071086:c5190808-5189891 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T195274 NZ_CP094470:1238909-1239268 [Faecalibacterium sp. I2-3-92]
GTGCAGGAATACGAGATCGAATTTTATGACAAAGCCGATGGCTCCGAACCGGCGAAAGAGTTTATTCTGGCTCTGGATGC
GAAAATGCGGGCTAAGGTCGTGCGCACGGTCGGGCTTCTCCGGGAGGAAGGGCCTTCACTGCGGGAGCCGTACTCCAAGC
ATCTGGAGGATGGCATTTTTGAGATCCGCACCAAGTTCGGCTCCGACATTACCCGTGTGCTGTACTTTTTTGTGATCGGC
AGAAGGATCATCCTTACGAACGGCTTTGTCAAAAAGACGCAGAAGACACCTGCTTCCGAGATCGCACTTGCAAAGCAGTA
CCGTGCCGATTATCTCAGCCGAAAGGAGTGCTCCAAATGA
GTGCAGGAATACGAGATCGAATTTTATGACAAAGCCGATGGCTCCGAACCGGCGAAAGAGTTTATTCTGGCTCTGGATGC
GAAAATGCGGGCTAAGGTCGTGCGCACGGTCGGGCTTCTCCGGGAGGAAGGGCCTTCACTGCGGGAGCCGTACTCCAAGC
ATCTGGAGGATGGCATTTTTGAGATCCGCACCAAGTTCGGCTCCGACATTACCCGTGTGCTGTACTTTTTTGTGATCGGC
AGAAGGATCATCCTTACGAACGGCTTTGTCAAAAAGACGCAGAAGACACCTGCTTCCGAGATCGCACTTGCAAAGCAGTA
CCGTGCCGATTATCTCAGCCGAAAGGAGTGCTCCAAATGA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT195274 WP_004177809.1 NZ_CP071086:c5191572-5190814 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT195274 NZ_CP094470:1239265-1239546 [Faecalibacterium sp. I2-3-92]
ATGACCAATTTCAATGATTTTCTCAACGAACAGATGAAAGACCCTGAGTTTAAGGCAGAGTGGGATGCCCTTGACCCCGA
ATTTGCTGTGATCGAGGCGATCCTTGCCGCCCGGAAGAAAAGCGGACTGACCCAGCAGCAGCTTTCCGAGCGCACCGGCA
TTGCCCAGACAGACATCAGCAAGCTGGAGCGCGGCAACGGAAATCCTTCGCTTCGCACCCTGCAGCGGCTGGCTGCCGGT
ATGGGGATGCGGGTCAAGATCGAATTTGTTCCGGCAAAGTGA
ATGACCAATTTCAATGATTTTCTCAACGAACAGATGAAAGACCCTGAGTTTAAGGCAGAGTGGGATGCCCTTGACCCCGA
ATTTGCTGTGATCGAGGCGATCCTTGCCGCCCGGAAGAAAAGCGGACTGACCCAGCAGCAGCTTTCCGAGCGCACCGGCA
TTGCCCAGACAGACATCAGCAAGCTGGAGCGCGGCAACGGAAATCCTTCGCTTCGCACCCTGCAGCGGCTGGCTGCCGGT
ATGGGGATGCGGGTCAAGATCGAATTTGTTCCGGCAAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A483YLF8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A6TH05 |