Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5026813..5027329 Replicon chromosome
Accession NZ_CP071086
Organism Klebsiella pneumoniae strain 3347689I

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag JY394_RS24970 Protein ID WP_004178374.1
Coordinates 5026813..5027097 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JY394_RS24975 Protein ID WP_002886901.1
Coordinates 5027087..5027329 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY394_RS24945 (JY394_24945) 5022230..5022493 - 264 WP_025987940.1 PTS sugar transporter subunit IIB -
JY394_RS24950 (JY394_24950) 5022623..5022796 + 174 WP_019725541.1 hypothetical protein -
JY394_RS24955 (JY394_24955) 5022799..5023542 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JY394_RS24960 (JY394_24960) 5023899..5026037 + 2139 WP_019725540.1 anaerobic ribonucleoside-triphosphate reductase -
JY394_RS24965 (JY394_24965) 5026345..5026809 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JY394_RS24970 (JY394_24970) 5026813..5027097 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JY394_RS24975 (JY394_24975) 5027087..5027329 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JY394_RS24980 (JY394_24980) 5027407..5029317 - 1911 WP_019725539.1 PRD domain-containing protein -
JY394_RS24985 (JY394_24985) 5029340..5030494 - 1155 WP_004178372.1 lactonase family protein -
JY394_RS24990 (JY394_24990) 5030561..5031301 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T195273 WP_004178374.1 NZ_CP071086:c5027097-5026813 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T195273 NZ_CP094468:1624466-1624657 [Faecalibacterium sp. I3-3-89]
ATGCCGATGACTCCCAAGCAAATGATTCGCTTGCTGGAGCAGAACGGCTTTGTTTTAGTCAGTGCAAATGGGTCACACTA
TAAGTACCATAACCCAACTACCAACAAAACCACTGTCGTTCCATTTCACGCAAAGGATCTGAAGCCCGGTACCGAGAAAA
ACATTCTCAAATTGGCCGGACTCAAAAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT195273 WP_002886901.1 NZ_CP071086:c5027329-5027087 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT195273 NZ_CP094468:1624798-1625175 [Faecalibacterium sp. I3-3-89]
ATGAACGCTATTTTCTATCCTGCAATTTTTCACCCGGAAGAAACCGGGTACTCTGTTGAGATTCCCGATATTGAGGGCTG
CTTCACCCAAGGCGATACCATGGACGAAGCTGTCCGCATGGCACAGGATGCCATCGGCCTTATGCTGGAAGATTGCAAAG
TCTGCCCGGAGCCTTCTGTCCCTTCTGCGCTTCACGTTGACCCGGAAGATTTTGTGGTGATGGTGCCTTTCGATATGGAA
GAGTACGAAAAGCGGTACAGACCCGTAAAGAAAACCCTTTCCATTCCCGGCTGGCTCAACGATGCCGCCGAATCGGCACA
CATCAACTTTTCCGGCGTCCTTCAGGATGCGCTGAAAGAGAAACTCCATCTGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References