Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4931638..4932329 Replicon chromosome
Accession NZ_CP071086
Organism Klebsiella pneumoniae strain 3347689I

Toxin (Protein)


Gene name ykfI Uniprot ID A0A483YFJ1
Locus tag JY394_RS24545 Protein ID WP_025987721.1
Coordinates 4931638..4931979 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A2A5MHA6
Locus tag JY394_RS24550 Protein ID WP_019725272.1
Coordinates 4932003..4932329 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY394_RS24530 (JY394_24530) 4928597..4929832 - 1236 WP_124044824.1 hypothetical protein -
JY394_RS24535 (JY394_24535) 4930292..4930693 - 402 WP_019725269.1 hypothetical protein -
JY394_RS24540 (JY394_24540) 4930690..4931523 - 834 WP_025987720.1 DUF4942 domain-containing protein -
JY394_RS24545 (JY394_24545) 4931638..4931979 - 342 WP_025987721.1 TA system toxin CbtA family protein Toxin
JY394_RS24550 (JY394_24550) 4932003..4932329 - 327 WP_019725272.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JY394_RS24555 (JY394_24555) 4932343..4932819 - 477 WP_019725273.1 DNA repair protein RadC -
JY394_RS24560 (JY394_24560) 4932829..4933275 - 447 WP_025987722.1 antirestriction protein -
JY394_RS24565 (JY394_24565) 4933487..4934176 - 690 WP_009309812.1 hypothetical protein -
JY394_RS24570 (JY394_24570) 4934741..4935631 - 891 WP_019725276.1 YfjP family GTPase -
JY394_RS24575 (JY394_24575) 4935714..4936802 - 1089 WP_019725277.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12867.90 Da        Isoelectric Point: 8.5195

>T195272 WP_025987721.1 NZ_CP071086:c4931979-4931638 [Klebsiella pneumoniae]
MKTLPATIQRAAKPCPSPVTVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQATGLLRQRHLPSIR

Download         Length: 342 bp

>T195272 NZ_CP094468:1210339-1210740 [Faecalibacterium sp. I3-3-89]
ATGAAATATATGCTGGATACAAACATCTGCATCTACGCCATGAAGCACAAACCGCCAGAGGCAATTAAGAACTTCTTGAT
GCATGACCCTGACGATATGTGCATTTCAGCAATCACTTATGGAGAACTGATGCATGGCGTAGAAAAGAGTCAAGCGGTGG
AACGAAACCGTGTTGCAGTCACGCTGTTCCTTTCTTCTATCGATATTCTCTCGTTTGACCACTACGCAGCAGAGGAATAT
GGTAAGGTACGAGCAGACCTTGAACGCAAGGGAACGCCGATTGGACCGATGGATATGCTGATAGCAGCTCATGCAAGATC
AGAAGGATTGATTCTTGTGACGAACAATACCAGAGAATTCTTCCGGGTAGAAGACTTGGAAGTGGAGGACTGGACGAAGT
AA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12276.01 Da        Isoelectric Point: 6.9560

>AT195272 WP_019725272.1 NZ_CP071086:c4932329-4932003 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFGDAECLKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR

Download         Length: 327 bp

>AT195272 NZ_CP094468:1210112-1210342 [Faecalibacterium sp. I3-3-89]
ATGATGACAGCAAAGTTGTTTGAGAATGGTCGTAGCCAAGCGGTTCGACTTCCTAAGGAATGTCGCTTCAATGGTGACGA
GGTTGCGATTAGCAAGGTTGGAGATGCCGTAATCCTTTTGCCAAAGGAAAACAGATGGTCTGGATTCCTGAGTAGTTTGG
ATTTGTTCTCTGATGATTTCATGAGTGAAGGTCGTGAACAGCCTGCAATGCAGGAGCGTGAATCCTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YFJ1

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MHA6

References