Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4268845..4269464 Replicon chromosome
Accession NZ_CP071086
Organism Klebsiella pneumoniae strain 3347689I

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JY394_RS21360 Protein ID WP_002892050.1
Coordinates 4269246..4269464 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JY394_RS21355 Protein ID WP_002892066.1
Coordinates 4268845..4269219 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY394_RS21345 (JY394_21345) 4263997..4265190 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JY394_RS21350 (JY394_21350) 4265213..4268359 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JY394_RS21355 (JY394_21355) 4268845..4269219 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JY394_RS21360 (JY394_21360) 4269246..4269464 + 219 WP_002892050.1 HHA domain-containing protein Toxin
JY394_RS21365 (JY394_21365) 4269623..4270189 + 567 WP_002892030.1 maltose O-acetyltransferase -
JY394_RS21370 (JY394_21370) 4270161..4270301 - 141 WP_004147370.1 hypothetical protein -
JY394_RS21375 (JY394_21375) 4270322..4270792 + 471 WP_002892026.1 YlaC family protein -
JY394_RS21380 (JY394_21380) 4270767..4272218 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JY394_RS21385 (JY394_21385) 4272319..4273017 + 699 WP_002892021.1 GNAT family protein -
JY394_RS21390 (JY394_21390) 4273014..4273154 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JY394_RS21395 (JY394_21395) 4273154..4273417 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T195270 WP_002892050.1 NZ_CP071086:4269246-4269464 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T195270 NZ_CP094467:168836-169126 [Faecalibacterium sp. I4-1-79]
ATGAGAGAAACAAAGCTGACCATCATCCCCACCACTCAGTTCCGCAAGGACTATAAGCTGGCCAGAAAACGGGGACTAAA
AATTGAACTGCTGCAGGATGTGATCGCTTGCCTTGCAATGGGAGAGCCGCTGCCGGAAAAGAACCGCGACCATGCCCTGA
CGGGTGATTGGGTCGGACACCGGGAGTGTCATATCCAGCCGGACTGGCTACTGGTCTATCGGGTGCAGAACGATGTTCTG
GTGCTGACCTTGACCCGCACTGGCACCCATAGTGATCTGTTTGGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT195270 WP_002892066.1 NZ_CP071086:4268845-4269219 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT195270 NZ_CP094467:168567-168839 [Faecalibacterium sp. I4-1-79]
ATGGCAACTACCAATGTCAGCATTCGGATGGATGCAGACCTGAAGGCGCAGGCCGATGCCCTGTTTGCAGAACTGGGCAT
GAACCTTTCCACCGCATTCAACATCTTTGTGCGGCAGTCCTTGCGGGAGGGCGGTATTCCCTTCGAGATCCGCACCGAGC
GCCCGAACAAGGAGACCGTGGCCGCTATGCTGGAAGCAGAGCATATCGCGGCAGACCCGAAGGCAAAGAAGTATCGGGAT
CTGGATGAGCTGTTTGCGGATCTGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References