Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2880349..2881937 Replicon chromosome
Accession NZ_CP071086
Organism Klebsiella pneumoniae strain 3347689I

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag JY394_RS14365 Protein ID WP_004199851.1
Coordinates 2880349..2881671 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JY394_RS14370 Protein ID WP_002904790.1
Coordinates 2881671..2881937 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY394_RS14350 (JY394_14355) 2875414..2877915 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
JY394_RS14355 (JY394_14360) 2877903..2878907 + 1005 WP_004199852.1 fimbrial protein -
JY394_RS14360 (JY394_14365) 2879040..2880332 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JY394_RS14365 (JY394_14370) 2880349..2881671 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
JY394_RS14370 (JY394_14375) 2881671..2881937 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JY394_RS14375 (JY394_14380) 2882203..2882529 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JY394_RS14380 (JY394_14385) 2882526..2883026 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JY394_RS14385 (JY394_14390) 2883004..2884383 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
JY394_RS14390 (JY394_14395) 2884729..2885883 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JY394_RS14395 (JY394_14400) 2885864..2886787 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T195269 WP_004199851.1 NZ_CP071086:c2881671-2880349 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T195269 NZ_CP094466:c2325284-2324994 [Faecalibacterium sp. I4-3-84]
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAGGACTACAAACGAGCCATCAAGCGTGGCTTGAA
GATTGAGCTGCTGGAGCAGGTCGTAGCATTGCTGGCAATGGGCGAGCCGCTGCCGGATAAAAACCGTGACCATGACCTGT
CCGGCGATTGGGCATGCCATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTATCGCATAGAGGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGATTTGTTCGGCAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT195269 WP_002904790.1 NZ_CP071086:c2881937-2881671 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT195269 NZ_CP094466:c2325559-2325281 [Faecalibacterium sp. I4-3-84]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACTGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTGTTTGCTGACCTGAAAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References