Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874354..875011 Replicon chromosome
Accession NZ_CP071086
Organism Klebsiella pneumoniae strain 3347689I

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JY394_RS04390 Protein ID WP_002916310.1
Coordinates 874601..875011 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JY394_RS04385 Protein ID WP_002916312.1
Coordinates 874354..874620 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY394_RS04360 (JY394_04360) 869510..870943 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
JY394_RS04365 (JY394_04365) 871062..871790 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JY394_RS04370 (JY394_04370) 871840..872151 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
JY394_RS04375 (JY394_04375) 872315..872974 + 660 WP_002916317.1 hemolysin III family protein -
JY394_RS04380 (JY394_04380) 873125..874108 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JY394_RS04385 (JY394_04385) 874354..874620 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JY394_RS04390 (JY394_04390) 874601..875011 + 411 WP_002916310.1 protein YgfX Toxin
JY394_RS04395 (JY394_04395) 875018..875539 - 522 WP_002916308.1 flavodoxin FldB -
JY394_RS04400 (JY394_04400) 875640..876536 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JY394_RS04405 (JY394_04405) 876559..877272 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JY394_RS04410 (JY394_04410) 877278..879011 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T195260 WP_002916310.1 NZ_CP071086:874601-875011 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T195260 NZ_CP094460:1252082-1252342 [Burkholderia pyrrocinia]
ATGCGCACGATTCATTTTTCGGATGCCCGCGGCAATCTGAAGACCGTCATCGACCAGGTTGTCGACGATGCGGACGTGAC
GCTCATCACGCGCCGCGATGCACCGAACGCCGTCATCATGTCGCAGGACTACTACGACAGCCTGATGGAGACGGTTCACT
TGCTGCGCTCGCCGGCCAACGTCGCCCATCTCGAACGTTCGATCGCGCAACTGCGCAAGGGCAAGGCGAAAGTACACAAG
CTCGCCGAGGATGGTGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT195260 WP_002916312.1 NZ_CP071086:874354-874620 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT195260 NZ_CP094460:1252339-1252605 [Burkholderia pyrrocinia]
ATGAGCGTACGCCGCGTGCTCGTTACTTCCGACGCGTGGGACGACTATGTCTATTGGCAGGGGCAGGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAGCCCAGCGAACGCCGTTCGAAGGCATCGGCAAACCCGAGCCTTTGAAGGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGACACGAACCGCCTGGTCTACGAGGCTGACGACCTTCAGATCAGCATC
GTGTCCTGTCGCTATCACTACGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References