Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2644537..2646125 Replicon chromosome
Accession NZ_CP071080
Organism Klebsiella pneumoniae strain 3347684I

Toxin (Protein)


Gene name hipA Uniprot ID W9B834
Locus tag JY393_RS12810 Protein ID WP_016529318.1
Coordinates 2644537..2645859 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A483IVM3
Locus tag JY393_RS12815 Protein ID WP_029496892.1
Coordinates 2645859..2646125 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY393_RS12795 (2639593) 2639593..2642094 + 2502 WP_032410312.1 fimbria/pilus outer membrane usher protein -
JY393_RS12800 (2642082) 2642082..2643086 + 1005 WP_009485243.1 fimbrial protein -
JY393_RS12805 (2643228) 2643228..2644520 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JY393_RS12810 (2644537) 2644537..2645859 - 1323 WP_016529318.1 type II toxin-antitoxin system HipA family toxin Toxin
JY393_RS12815 (2645859) 2645859..2646125 - 267 WP_029496892.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JY393_RS12820 (2646512) 2646512..2646838 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JY393_RS12825 (2646835) 2646835..2647335 - 501 WP_020804988.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JY393_RS12830 (2647313) 2647313..2648692 - 1380 WP_020804975.1 nucleobase:cation symporter-2 family protein -
JY393_RS12835 (2649038) 2649038..2650192 + 1155 WP_020804972.1 FAD-dependent urate hydroxylase HpxO -
JY393_RS12840 (2650173) 2650173..2651096 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-64)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5366

>T195249 WP_016529318.1 NZ_CP071080:c2645859-2644537 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T195249 NZ_CP094453:c81308-81159 [Klebsiella pneumoniae subsp. rhinoscleromatis]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9938.33 Da        Isoelectric Point: 8.5912

>AT195249 WP_029496892.1 NZ_CP071080:c2646125-2645859 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGMVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT195249 NZ_CP094453:81353-81412 [Klebsiella pneumoniae subsp. rhinoscleromatis]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9B834

Antitoxin

Source ID Structure
AlphaFold DB A0A483IVM3

References