Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 809141..809798 Replicon chromosome
Accession NZ_CP071080
Organism Klebsiella pneumoniae strain 3347684I

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JY393_RS04020 Protein ID WP_002916310.1
Coordinates 809388..809798 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JY393_RS04015 Protein ID WP_002916312.1
Coordinates 809141..809407 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY393_RS03990 (804297) 804297..805730 - 1434 WP_211652330.1 6-phospho-beta-glucosidase -
JY393_RS03995 (805849) 805849..806577 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JY393_RS04000 (806627) 806627..806938 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JY393_RS04005 (807102) 807102..807761 + 660 WP_002916317.1 hemolysin III family protein -
JY393_RS04010 (807912) 807912..808895 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JY393_RS04015 (809141) 809141..809407 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JY393_RS04020 (809388) 809388..809798 + 411 WP_002916310.1 protein YgfX Toxin
JY393_RS04025 (809805) 809805..810326 - 522 WP_002916308.1 flavodoxin FldB -
JY393_RS04030 (810427) 810427..811323 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JY393_RS04035 (811346) 811346..812059 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JY393_RS04040 (812065) 812065..813798 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T195240 WP_002916310.1 NZ_CP071080:809388-809798 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T195240 NZ_CP094451:915208-915615 [Klebsiella pneumoniae subsp. rhinoscleromatis]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT195240 WP_002916312.1 NZ_CP071080:809141-809407 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT195240 NZ_CP094451:914961-915227 [Klebsiella pneumoniae subsp. rhinoscleromatis]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References