Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1203056..1203674 Replicon chromosome
Accession NZ_CP071073
Organism Escherichia coli strain 3347558

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JY392_RS05750 Protein ID WP_001291435.1
Coordinates 1203056..1203274 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JY392_RS05755 Protein ID WP_000344800.1
Coordinates 1203300..1203674 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY392_RS05715 (1198345) 1198345..1198917 + 573 WP_000779826.1 YbaY family lipoprotein -
JY392_RS05720 (1198948) 1198948..1199259 - 312 WP_000409911.1 MGMT family protein -
JY392_RS05730 (1199638) 1199638..1199991 + 354 WP_000878140.1 DUF1428 domain-containing protein -
JY392_RS05735 (1200033) 1200033..1201583 - 1551 Protein_1127 cyclic-guanylate-specific phosphodiesterase PdeB -
JY392_RS05740 (1201747) 1201747..1202217 - 471 WP_000136192.1 YlaC family protein -
JY392_RS05745 (1202333) 1202333..1202884 - 552 WP_000102559.1 maltose O-acetyltransferase -
JY392_RS05750 (1203056) 1203056..1203274 - 219 WP_001291435.1 HHA domain-containing protein Toxin
JY392_RS05755 (1203300) 1203300..1203674 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JY392_RS05760 (1204220) 1204220..1207369 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
JY392_RS05765 (1207392) 1207392..1208585 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T195207 WP_001291435.1 NZ_CP071073:c1203274-1203056 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T195207 NZ_CP094359:1433686-1433973 [Acidithiobacillus sp. YTS05]
ATGACCTATAGCCTCGAATTCCGGGATAGCGCCTGGAAGGAGTGGCAAAAGCTCGACCGCCTGTTGCGCGAACAATTCAA
GGCCAAGCTGCTGGAGCGGCTGGAAAACCCCCGCGTCGAATCCGCCCGGCTCTCGGGCATGCCCGACTGCTACAAGATCA
AGCTGCGCGCCGCCGGATACCGGCTGGTCTATCGGATATTCGACGAACGCGTCGTGGTGGTCGTAGTGGCCGTGGGCAAG
CGGGAGGACAGCGCCGTGTATCGCAAGGCGAAGGGGCGGATGAAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT195207 WP_000344800.1 NZ_CP071073:c1203674-1203300 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT195207 NZ_CP094359:1433451-1433696 [Acidithiobacillus sp. YTS05]
ATGGAAATTCTGTATACCAACGCATCAATCAGCATCAGTGAGCTGAAAAAGAACCCTTCTGCGGTTATCGAGGAAGCGGA
CGGCTTTCCTGTTGCCGTGCTCAACCACAACAGACCCGCCGCTTATCTGGTGCCCGCTGCTGCGTTCGAGGCCATGATCG
AAAAGCTCGACGACATCGAACTGGTCCGCATGGTGAAGGAGCGCGAACACGAGCCCACCATCAAGGTCTCGCCCGATGAC
CTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References