Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
| Location | 4038415..4039118 | Replicon | chromosome |
| Accession | NZ_CP071070 | ||
| Organism | Citrobacter sedlakii strain 3347689II | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | - |
| Locus tag | JY391_RS19170 | Protein ID | WP_211934844.1 |
| Coordinates | 4038415..4038756 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | - |
| Locus tag | JY391_RS19175 | Protein ID | WP_211934845.1 |
| Coordinates | 4038777..4039118 (-) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JY391_RS19150 (JY391_19150) | 4033606..4035351 | + | 1746 | WP_211934842.1 | DNA primase | - |
| JY391_RS19155 (JY391_19155) | 4035610..4037457 | + | 1848 | WP_042289358.1 | RNA polymerase sigma factor RpoD | - |
| JY391_RS19160 (JY391_19160) | 4037546..4038052 | - | 507 | WP_211934843.1 | G/U mismatch-specific DNA glycosylase | - |
| JY391_RS19170 (JY391_19170) | 4038415..4038756 | - | 342 | WP_211934844.1 | TA system toxin CbtA family protein | Toxin |
| JY391_RS19175 (JY391_19175) | 4038777..4039118 | - | 342 | WP_211934845.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| JY391_RS19180 (JY391_19180) | 4039129..4039671 | - | 543 | WP_211934846.1 | DNA repair protein RadC | - |
| JY391_RS19185 (JY391_19185) | 4039684..4040127 | - | 444 | WP_044865636.1 | antirestriction protein | - |
| JY391_RS19190 (JY391_19190) | 4040158..4040979 | - | 822 | WP_211934847.1 | DUF932 domain-containing protein | - |
| JY391_RS19195 (JY391_19195) | 4041099..4041572 | - | 474 | WP_211934848.1 | hypothetical protein | - |
| JY391_RS19200 (JY391_19200) | 4041644..4042096 | - | 453 | WP_077264947.1 | hypothetical protein | - |
| JY391_RS19205 (JY391_19205) | 4042132..4042848 | - | 717 | WP_021571976.1 | WYL domain-containing protein | - |
| JY391_RS19210 (JY391_19210) | 4043092..4043967 | - | 876 | WP_211934849.1 | GTPase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12759.57 Da Isoelectric Point: 6.7156
>T195195 WP_211934844.1 NZ_CP071070:c4038756-4038415 [Citrobacter sedlakii]
MKTLPATNPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVDKYELVRIDHRGF
NWQEQSPYLRAVDLLRARQATGLLRRSRNNAVS
MKTLPATNPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVDKYELVRIDHRGF
NWQEQSPYLRAVDLLRARQATGLLRRSRNNAVS
Download Length: 342 bp
>T195195 NZ_CP094351:3695850-3696422 [Pseudomonas orientalis]
ATGGACTTCGAAAAAATCAAAGGTCGCCTCGACTTTTTGCGCGAAGCGGAGAAACTCAAGGATGTGCTCAGAAGTGCCCA
CACCGCTTCGGGACGCACCGAAAGTACCGCCGAACACAGTTGGCGCCTGTGCCTGATGGCGATGGTATTCGCCGACCAAC
TGCCCGGCCTGGACCTGCTTAAAATCCTCAAAATGTGCGTGATCCATGACTTGGGCGAAGCCATCAACGGTGATATCCCG
GCCGTCAGCCAGGCGGCGTTTCCCGACAAGGGCGAGCAGGAACGACGCGACCTGCTGCTATTGACCCAAACCCTGGACGG
CGCCCTGAAAACACAGATCATGGCGCTATGGGATGACTACGAGAACGCGCTGTCACCGGAAGCGAAAGCCGTCAAGGCGA
TGGACAAACTGGAGACCCTGCTGCAGCACACCCAGGGCCTCAACCCGCCGGATTTCGACTACGCCTTCAACCTGGCGTAC
GGCAAGAAGCATACGGATGCCGAGCCGTTATTCGAGGCGCTGCGCGCGCTGATCGACCGCGCTACCCAGGAGCGCCTCGA
CGCCGGTGACTGA
ATGGACTTCGAAAAAATCAAAGGTCGCCTCGACTTTTTGCGCGAAGCGGAGAAACTCAAGGATGTGCTCAGAAGTGCCCA
CACCGCTTCGGGACGCACCGAAAGTACCGCCGAACACAGTTGGCGCCTGTGCCTGATGGCGATGGTATTCGCCGACCAAC
TGCCCGGCCTGGACCTGCTTAAAATCCTCAAAATGTGCGTGATCCATGACTTGGGCGAAGCCATCAACGGTGATATCCCG
GCCGTCAGCCAGGCGGCGTTTCCCGACAAGGGCGAGCAGGAACGACGCGACCTGCTGCTATTGACCCAAACCCTGGACGG
CGCCCTGAAAACACAGATCATGGCGCTATGGGATGACTACGAGAACGCGCTGTCACCGGAAGCGAAAGCCGTCAAGGCGA
TGGACAAACTGGAGACCCTGCTGCAGCACACCCAGGGCCTCAACCCGCCGGATTTCGACTACGCCTTCAACCTGGCGTAC
GGCAAGAAGCATACGGATGCCGAGCCGTTATTCGAGGCGCTGCGCGCGCTGATCGACCGCGCTACCCAGGAGCGCCTCGA
CGCCGGTGACTGA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12888.44 Da Isoelectric Point: 5.0743
>AT195195 WP_211934845.1 NZ_CP071070:c4039118-4038777 [Citrobacter sedlakii]
MKSTDSENDTFLQWGLNRNVTPCFGARLVQEGNRLHYLADRVSITGEFSNAESLKLDEVFPRFISQMESMLTTGEMNPRY
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTQR
MKSTDSENDTFLQWGLNRNVTPCFGARLVQEGNRLHYLADRVSITGEFSNAESLKLDEVFPRFISQMESMLTTGEMNPRY
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTQR
Download Length: 342 bp
>AT195195 NZ_CP094351:3695204-3695761 [Pseudomonas orientalis]
ATGCCCGCTTTGATCCTCCAGCCAGCCATTCCGGGCATTGCGCTGCGCCGATGGCGGGTACTGCACCGCGTCAAACAAAC
CCATGCGGCGCAGATGTTCAACGTGAACCAATCGACGCTGTCCCGTTGGGAGAATGGCGTACAGGCAATGGATGCCGCTG
CGCACCAACAGCTCGAACGGTTGCTGTCCGCCCGGCTTGACAGCGCAGCTGATCAGGCCCTGGCGGGTCTGGTCAGGGAA
AGCCCACGCGCAGTGCACCTGGTGTGCGACCTGACCCACCGCCTGCTGGCTTGCTCGCCCTCGCGCGCGGCCCAGTTCAG
CCGCCCATTGGTCGACCTGACAGGCCAATCGTTGTGGCGTTACGCAACCCCGCAGATCCGTCAGGCCGAAGCCGCTCTGG
ATCACACGGGCTGGCGAGATACCCAGGCGCCGCCGGCACTTCAATTTTGCACCGGCAGCAACGGCTCCAGCCTCGTGCCG
ATCCGCCCGAGCCTGTGTCGCTGGACGCGCATGATCCTCAGCGACGGCAGCGCCGCGCGTCTGGTCGAGACCCTGTGA
ATGCCCGCTTTGATCCTCCAGCCAGCCATTCCGGGCATTGCGCTGCGCCGATGGCGGGTACTGCACCGCGTCAAACAAAC
CCATGCGGCGCAGATGTTCAACGTGAACCAATCGACGCTGTCCCGTTGGGAGAATGGCGTACAGGCAATGGATGCCGCTG
CGCACCAACAGCTCGAACGGTTGCTGTCCGCCCGGCTTGACAGCGCAGCTGATCAGGCCCTGGCGGGTCTGGTCAGGGAA
AGCCCACGCGCAGTGCACCTGGTGTGCGACCTGACCCACCGCCTGCTGGCTTGCTCGCCCTCGCGCGCGGCCCAGTTCAG
CCGCCCATTGGTCGACCTGACAGGCCAATCGTTGTGGCGTTACGCAACCCCGCAGATCCGTCAGGCCGAAGCCGCTCTGG
ATCACACGGGCTGGCGAGATACCCAGGCGCCGCCGGCACTTCAATTTTGCACCGGCAGCAACGGCTCCAGCCTCGTGCCG
ATCCGCCCGAGCCTGTGTCGCTGGACGCGCATGATCCTCAGCGACGGCAGCGCCGCGCGTCTGGTCGAGACCCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|