195194

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3397241..3397861 Replicon chromosome
Accession NZ_CP071070
Organism Citrobacter sedlakii strain 3347689II

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JY391_RS16335 Protein ID WP_001280991.1
Coordinates 3397643..3397861 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0V9JYC1
Locus tag JY391_RS16330 Protein ID WP_042285841.1
Coordinates 3397241..3397615 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY391_RS16320 (JY391_16320) 3392382..3393575 + 1194 WP_042285835.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JY391_RS16325 (JY391_16325) 3393598..3396747 + 3150 WP_042285838.1 efflux RND transporter permease AcrB -
JY391_RS16330 (JY391_16330) 3397241..3397615 + 375 WP_042285841.1 Hha toxicity modulator TomB Antitoxin
JY391_RS16335 (JY391_16335) 3397643..3397861 + 219 WP_001280991.1 HHA domain-containing protein Toxin
JY391_RS16340 (JY391_16340) 3398039..3398596 + 558 WP_042285845.1 maltose O-acetyltransferase -
JY391_RS16345 (JY391_16345) 3398704..3399174 + 471 WP_042285848.1 YlaC family protein -
JY391_RS16350 (JY391_16350) 3399222..3399362 - 141 WP_016537667.1 type B 50S ribosomal protein L36 -
JY391_RS16355 (JY391_16355) 3399365..3399625 - 261 WP_042285853.1 type B 50S ribosomal protein L31 -
JY391_RS16360 (JY391_16360) 3399804..3401354 + 1551 WP_211934658.1 EAL domain-containing protein -
JY391_RS16365 (JY391_16365) 3401394..3401747 - 354 WP_211934659.1 DUF1428 family protein -
JY391_RS16370 (JY391_16370) 3401828..3402424 - 597 WP_199956500.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T195194 WP_001280991.1 NZ_CP071070:3397643-3397861 [Citrobacter sedlakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T195194 NZ_CP094351:c2310627-2310376 [Pseudomonas orientalis]
GTGTCCAAAAATGAAAAGCTGCTCGCCAAACTGCTCAATGAGCACATGGCATTCACCTGGTCCGAGCTCGTAACGTTGTT
GCGCCGACTGGGCTACACACAGATTGAAGGGGCTGGAAGCCGGGTCAAATTCGATATCGGCGACCCCAGTGCACTGATTA
CCCTGCACAAGCCTCACCCCGGCAACGAACTGAAACACTACATTCGGCGCCAAATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14467.25 Da        Isoelectric Point: 4.7077

>AT195194 WP_042285841.1 NZ_CP071070:3397241-3397615 [Citrobacter sedlakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWQKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT195194 NZ_CP094351:c2310379-2310026 [Pseudomonas orientalis]
GTGAACAACCAGCTCAAACACAAAGGCTACATCGGCTCCATCGAAGCCAGCCTCGAAGACAACTGCCTGTTCGGCAAAAT
CCTGTTCATCAAGGCGTTGGTGAGCTACGAAGGCAAAACCGTCGCCGAGTTGGACGCGGCTTTCAAGGAGGCGGTGGACG
ATTACCTGGCAACCTGCCAAGCCCTCGGGCAAACGCCGGAAAAGCCTTGCAAGGGCTCCTTCAACGTACGCGTGGGCCAT
GATCTGCATTTGGCGGCAGCGCTGGCGGCGACCCGTAAGAAGGTGACGTTGAACGACCTGACCCGCCAGGCGCTGAATGA
GTTTTTACAACATCATTGCCCTGCGATTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9JYC1

References