195185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 810337..810991 Replicon chromosome
Accession NZ_CP071070
Organism Citrobacter sedlakii strain 3347689II

Toxin (Protein)


Gene name cptA Uniprot ID A0A0V9JTV0
Locus tag JY391_RS03870 Protein ID WP_042292137.1
Coordinates 810584..810991 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9JTE1
Locus tag JY391_RS03865 Protein ID WP_042292140.1
Coordinates 810337..810603 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY391_RS03840 (JY391_03840) 805534..806967 - 1434 WP_205612322.1 6-phospho-beta-glucosidase -
JY391_RS03845 (JY391_03845) 807085..807813 - 729 WP_060569471.1 MurR/RpiR family transcriptional regulator -
JY391_RS03850 (JY391_03850) 807866..808177 + 312 WP_042292149.1 N(4)-acetylcytidine aminohydrolase -
JY391_RS03855 (JY391_03855) 808340..808999 + 660 WP_211935244.1 hemolysin III family protein -
JY391_RS03860 (JY391_03860) 809100..810080 - 981 WP_181822563.1 tRNA-modifying protein YgfZ -
JY391_RS03865 (JY391_03865) 810337..810603 + 267 WP_042292140.1 FAD assembly factor SdhE Antitoxin
JY391_RS03870 (JY391_03870) 810584..810991 + 408 WP_042292137.1 protein YgfX Toxin
JY391_RS03875 (JY391_03875) 811036..811557 - 522 WP_042292135.1 flavodoxin FldB -
JY391_RS03880 (JY391_03880) 811657..812553 + 897 WP_042292373.1 site-specific tyrosine recombinase XerD -
JY391_RS03885 (JY391_03885) 812577..813290 + 714 WP_211935245.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JY391_RS03890 (JY391_03890) 813296..815029 + 1734 WP_211935246.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15916.91 Da        Isoelectric Point: 10.5720

>T195185 WP_042292137.1 NZ_CP071070:810584-810991 [Citrobacter sedlakii]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINACQGEVKLLMDGRLRWQGR
EWTIVSAPWIIKTGMMLRLRSESGKRQHLWLAADSMDEAEWRDLCRLMLQQSMQR

Download         Length: 408 bp

>T195185 NZ_CP094343:c6183008-6182826 [Pseudomonas sp. M1]
ATGCGCAGTCGAGAAATCATGGAGTTGATCCGGGCGGATGGCTGGTTCCTGGTGGAGGTGAAAGGCAGTCATCATCAGTT
CCGGCATTTCACCAAGAAGGGGCGGGTGACGGTTCCCCACCCCAGGAGCAACCTGCCGATCGGGACCGTGAACAGCATTC
TGCGCCAGGCCGGCCTGCGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1496

>AT195185 WP_042292140.1 NZ_CP071070:810337-810603 [Citrobacter sedlakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFVRLLECDDPDLFNWLMNHGKPADVELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT195185 NZ_CP094343:c6182793-6182389 [Pseudomonas sp. M1]
ATGAAATTCCCCGTGGTTCTGCACAAGGACGCCGACTCGGATTACGGCGTGACCATCCCTGACGTGCCTGGCTGCTTCTC
CGCCGGCGGCACCGTCAGCCAGGCGCTGGAAAACGTCCAGGAAGCCCTGGCCCTGCACTTCGAAGGCCTGGTGGCCGACG
GCGAGACGCTCCCGCAAGCCCAGGAAGTGGACACCCACATGGGCAACCCCGACTACGCCGGCGGCGTCTGGGCGGTGGTC
GACTTCGACGTCACCCCCTACCTGGGCAAGGCCGTGCGCTTCAACGCCAGCCTCCCGGAAAACCTCCTGCAACGCATCGA
CGAACGCGTGAAGCGCGACCATCGCTACGCCTCTCGCTCCGGCTTCCTGGCTACCGCCGCGCTGCGTGAGTTGTCTTCGA
ACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9JTV0

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9JTE1

References