Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 294220..294851 Replicon chromosome
Accession NZ_CP071070
Organism Citrobacter sedlakii strain 3347689II

Toxin (Protein)


Gene name hicA Uniprot ID A0A0V9JK06
Locus tag JY391_RS01335 Protein ID WP_042286656.1
Coordinates 294220..294495 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7L6Y5R2
Locus tag JY391_RS01340 Protein ID WP_042286652.1
Coordinates 294492..294851 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY391_RS01325 (JY391_01325) 290227..292971 + 2745 WP_211935116.1 ribosome-associated ATPase/putative transporter RbbA -
JY391_RS01330 (JY391_01330) 292971..294095 + 1125 WP_042286658.1 ABC transporter permease -
JY391_RS01335 (JY391_01335) 294220..294495 + 276 WP_042286656.1 type II toxin-antitoxin system HicA family toxin Toxin
JY391_RS01340 (JY391_01340) 294492..294851 + 360 WP_042286652.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JY391_RS01345 (JY391_01345) 294933..295334 - 402 WP_042286649.1 nickel-responsive transcriptional regulator NikR -
JY391_RS01350 (JY391_01350) 295347..296147 - 801 WP_181822380.1 nickel import ATP-binding protein NikE -
JY391_RS01355 (JY391_01355) 296144..296908 - 765 WP_211935117.1 nickel import ATP-binding protein NikD -
JY391_RS01360 (JY391_01360) 296908..297741 - 834 WP_211935118.1 nickel ABC transporter permease subunit NikC -
JY391_RS01365 (JY391_01365) 297738..298682 - 945 WP_042286639.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10307.04 Da        Isoelectric Point: 10.6850

>T195183 WP_042286656.1 NZ_CP071070:294220-294495 [Citrobacter sedlakii]
MRQQVLSLRKKQRNTLEQLFKTPVPQAIKWLDIESLVKALGGEIKEGRGSRCKFLLNNSIACFHRPHPSPDTDKGAVESV
RDWLISIGVKP

Download         Length: 276 bp

>T195183 NZ_CP094343:c5766156-5765905 [Pseudomonas sp. M1]
ATGTCCAGGAACGAGAAACTGCTGGCCAAGCTACTCAACGAAAGCGCCAGCTTTACCTGGCAGGAGCTTGTGACACTACT
GCGTTGGCTGGGCTACAGGCAGTTGGAGGGCAGCGGGAGCCGGGTCAAGTTCGACAACGGCGACCCGCAGGCGTTGATCA
ACCTTCACAAGCCGCACCCGGGCAACGAGCTGAAAGCCTATGTCCGGCGCCAGATCATCGAGCACCTCAAGGCGGGGGAA
CTGATTCCGTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13271.98 Da        Isoelectric Point: 4.7582

>AT195183 WP_042286652.1 NZ_CP071070:294492-294851 [Citrobacter sedlakii]
MIKPKTPNAMEIAGHPAVIHYVPELNAFRGKFLGLSGHCDFVSDSIQGLQEEGEISLNEYLADCREAGIEPYAHTEKMKT
FTLRYPESFGERLSSAAAEEQVSVNTWIIDTLSERLKQA

Download         Length: 360 bp

>AT195183 NZ_CP094343:c5765908-5765567 [Pseudomonas sp. M1]
GTGAACAACCTGCTGCAATACCGGGGCTATTACGGCTCCATCGAAGCCAGCACCGAGGACAACTGCCTGTTCGGCAAGCT
GCTCTTCATCCGCGCGCTGGTCAACTACGAAGGCGAGACGGTGGCCGAACTGCAGGCCGCTTTCCGCGAGGCGGTGGACG
ACTACCTGGCCACATGCCAGGCGCAGGGGCAGGAGCCGGAAGTGCCTTGCAAGGGATCGTTCAACGTGCGGGTCGGCCAT
GACTTGCATCTGGCAGCGAGCCTGGCAGCCAATCGGCAGCACATGAGCCTGAACGACCTCACCCGGCAGGCGCTGAGCGA
GTATTTGCAGCACCACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9JK06

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6Y5R2

References