Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 4701255..4701871 Replicon chromosome
Accession NZ_CP071063
Organism Enterobacter mori strain 08-091

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JY395_RS22190 Protein ID WP_109492490.1
Coordinates 4701255..4701626 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JY395_RS22195 Protein ID WP_109492491.1
Coordinates 4701629..4701871 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY395_RS22175 (JY395_22160) 4698755..4699657 + 903 WP_214598973.1 formate dehydrogenase subunit beta -
JY395_RS22180 (JY395_22165) 4699654..4700289 + 636 WP_010436852.1 formate dehydrogenase cytochrome b556 subunit -
JY395_RS22185 (JY395_22170) 4700286..4701215 + 930 WP_010436850.1 formate dehydrogenase accessory protein FdhE -
JY395_RS22190 (JY395_22175) 4701255..4701626 - 372 WP_109492490.1 type II toxin-antitoxin system VapC family toxin Toxin
JY395_RS22195 (JY395_22180) 4701629..4701871 - 243 WP_109492491.1 ribbon-helix-helix protein, CopG family Antitoxin
JY395_RS22200 (JY395_22185) 4701991..4702932 - 942 WP_042716391.1 fatty acid biosynthesis protein FabY -
JY395_RS22205 (JY395_22190) 4702977..4703414 - 438 WP_014833798.1 D-aminoacyl-tRNA deacylase -
JY395_RS22210 (JY395_22195) 4703432..4704292 - 861 WP_215230425.1 virulence factor BrkB family protein -
JY395_RS22215 (JY395_22200) 4704286..4704885 - 600 WP_100167578.1 glucose-1-phosphatase -
JY395_RS22220 (JY395_22205) 4705018..4706841 - 1824 WP_100167579.1 ribosome-dependent GTPase TypA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-109)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13594.73 Da        Isoelectric Point: 6.8715

>T195180 WP_109492490.1 NZ_CP071063:c4701626-4701255 [Enterobacter mori]
MEQMAVFDTNILIDLFNNRVEAADAIDRTASHRAISLITWMEVMVGARKHGHEAKTAAVMGAFEIVDITREIAERSVLLR
EKHGMKLPDAIILATAQSRSCPLISRNTKDFSGITGVVSPYQL

Download         Length: 372 bp

>T195180 NZ_CP071063:c4701626-4701255 [Enterobacter mori]
ATGGAGCAGATGGCAGTGTTTGATACCAATATTCTCATCGATCTTTTTAATAATCGCGTTGAGGCGGCGGATGCCATTGA
TCGCACGGCGTCGCATAGAGCCATTAGCCTGATCACATGGATGGAAGTCATGGTGGGTGCGCGCAAGCACGGACATGAAG
CAAAAACGGCGGCTGTGATGGGGGCCTTTGAAATTGTTGATATCACGCGGGAGATTGCTGAAAGAAGCGTATTACTCCGC
GAGAAGCACGGCATGAAGCTGCCCGATGCCATCATTCTGGCAACCGCTCAGAGCAGAAGTTGCCCGTTAATCTCACGCAA
TACGAAAGACTTTTCGGGCATCACCGGGGTCGTTTCACCTTACCAGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9469.67 Da        Isoelectric Point: 4.2803

>AT195180 WP_109492491.1 NZ_CP071063:c4701871-4701629 [Enterobacter mori]
MTLLADLDMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT195180 NZ_CP071063:c4701871-4701629 [Enterobacter mori]
ATGACTCTTTTGGCGGACCTTGATATGGGCAGAATACTGATCGATTTGTCTGATGACGTGATTCAGCGACTGGATAACCT
GAAGCAACTGCGTAACCGGCCCCGCGCCGAATTGCTACGGGAAGCTATTGAGCAATATCTCGACCAGCAGAGTTCATCGG
TTATCCGCGATGCGCTTGGCCTGTGGGGAAACCAGCAGGAAGATGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References