Detailed information of TA system TA195179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4577064..4577671
• Replicon: chromosome
• Accession: NZ_CP071063
• Organism: Enterobacter mori strain 08-091

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2T4Y605
• Locus tag: JY395_RS21625
• Protein ID: WP_041911637.1
• Coordinates: 4577486..4577671 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JY395_RS21620
• Protein ID: WP_215230398.1
• Coordinates: 4577064..4577471 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JY395_RS21605 (JY395_21590)	4572418..4573818	+	1401	WP_215230396.1	MFS transporter	-
JY395_RS21610 (JY395_21595)	4573829..4575778	+	1950	WP_215230397.1	glycoside hydrolase family 127 protein	-
JY395_RS21615 (JY395_21600)	4575984..4577060	+	1077	WP_214599061.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
JY395_RS21620 (JY395_21605)	4577064..4577471	-	408	WP_215230398.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JY395_RS21625 (JY395_21610)	4577486..4577671	-	186	WP_041911637.1	type II toxin-antitoxin system HicA family toxin	Toxin
JY395_RS21630 (JY395_21615)	4577881..4578621	-	741	WP_109492510.1	MipA/OmpV family protein	-
JY395_RS21635 (JY395_21620)	4578739..4579704	+	966	WP_100165410.1	LysR family transcriptional regulator	-
JY395_RS21640 (JY395_21625)	4579701..4581239	-	1539	WP_042716601.1	aldehyde dehydrogenase family protein	-
JY395_RS21645 (JY395_21630)	4581405..4582289	+	885	WP_215230399.1	ROK family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6852.04 Da
• Isoelectric Point: 11.2341

>T195179 WP_041911637.1 NZ_CP071063:c4577671-4577486 [Enterobacter mori]
VKSADVITVLIGHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T195179 NZ_CP094343:4542688-4543044 [Pseudomonas sp. M1]
ATGGTGAGGCGCCCGCCGAGCGTTCCCGACCGCGGTGAGATCTGGCACTTGCAGTTCGATCCCTCGACGGGCCGTGAAAT
GATCGGCGACCACTTTTGCCTGGTCCTGTCGAAACGCGAATTCAATGAAATGGGCCTGGCCCTGGTCTGCCCCATCTCGC
AAGGCGCATCCAATGTGGCGCGCAACCAGGGCTTCCTTGTCACCCTGATGGGCGAAGGCACCGATACCCAGGGCAATGTC
CACAGCCACCAGGTGCGGACGCTGGACTGGAGGGCGCGCCGAGCCGCATTCAAGGAAAAGGCCCCCGATTCCGTAACCAA
CTACGTGCTTTCGCTGGTCGGGGCGATCCTGGAGTAG

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15013.74 Da
• Isoelectric Point: 4.3197

>AT195179 WP_215230398.1 NZ_CP071063:c4577471-4577064 [Enterobacter mori]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALSAHFEALFEMDDALPLPGNVEAHLESRPEDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSYVSEHPQFGNRSAFLAEAARRVLPG

Nucleotide

• Length: 408 bp

>AT195179 NZ_CP094343:4542455-4542694 [Pseudomonas sp. M1]
ATGACCACGCTTGCCCTGCGCAAATCCGGGGGGTCCCTGATCATTTCGGTTCCCTCGGCCTTCGTCGCCCAGAACAAACT
GCACGCTGGCAGTCAGGTTGAGTGCGACATCGTTGAGGGAGCCCTGGTGATCAAGCCGATGACGCGCCCGAGCCTGGCCC
AACTGATCGCCGAAACGCCCAAAGACTCGCTCGCCCCGGACTGGGACAGCATGCCGGCCGTAGGCGCGGAACAATGGTGA

Structures

Toxin

• AlphaFold DB: A0A2T4Y605