Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1067221..1067841 Replicon chromosome
Accession NZ_CP071063
Organism Enterobacter mori strain 08-091

Toxin (Protein)


Gene name Hha Uniprot ID V3PUI7
Locus tag JY395_RS05005 Protein ID WP_010428174.1
Coordinates 1067221..1067439 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag JY395_RS05010 Protein ID WP_008499288.1
Coordinates 1067467..1067841 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY395_RS04975 (JY395_04965) 1063231..1063491 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
JY395_RS04980 (JY395_04970) 1063494..1063634 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
JY395_RS04985 (JY395_04975) 1063631..1064341 - 711 WP_042714803.1 GNAT family protein -
JY395_RS04990 (JY395_04980) 1064443..1065903 + 1461 WP_215230704.1 PLP-dependent aminotransferase family protein -
JY395_RS04995 (JY395_04985) 1065875..1066342 - 468 WP_042714806.1 YlaC family protein -
JY395_RS05000 (JY395_04990) 1066460..1067011 - 552 WP_215230705.1 maltose O-acetyltransferase -
JY395_RS05005 (JY395_04995) 1067221..1067439 - 219 WP_010428174.1 HHA domain-containing protein Toxin
JY395_RS05010 (JY395_05000) 1067467..1067841 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
JY395_RS05015 (JY395_05005) 1068351..1071497 - 3147 WP_042716155.1 multidrug efflux RND transporter permease subunit AcrB -
JY395_RS05020 (JY395_05010) 1071520..1072713 - 1194 WP_042716154.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8597.97 Da        Isoelectric Point: 8.9008

>T195167 WP_010428174.1 NZ_CP071063:c1067439-1067221 [Enterobacter mori]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T195167 NZ_CP094339:c4625094-4624921 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT195167 WP_008499288.1 NZ_CP071063:c1067841-1067467 [Enterobacter mori]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT195167 NZ_CP094339:c4625418-4625122 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V3PUI7

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References