Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 469287..469803 Replicon chromosome
Accession NZ_CP071063
Organism Enterobacter mori strain 08-091

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JY395_RS02285 Protein ID WP_215230539.1
Coordinates 469519..469803 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag JY395_RS02280 Protein ID WP_008501400.1
Coordinates 469287..469529 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY395_RS02265 (JY395_02260) 465287..466027 + 741 WP_100165612.1 KDGP aldolase family protein -
JY395_RS02270 (JY395_02265) 466143..467279 + 1137 WP_215230537.1 lactonase family protein -
JY395_RS02275 (JY395_02270) 467299..469209 + 1911 WP_215230538.1 PRD domain-containing protein -
JY395_RS02280 (JY395_02275) 469287..469529 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JY395_RS02285 (JY395_02280) 469519..469803 + 285 WP_215230539.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JY395_RS02290 (JY395_02285) 469807..470271 - 465 WP_100165609.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JY395_RS02295 (JY395_02290) 470400..472538 - 2139 WP_215230540.1 anaerobic ribonucleoside-triphosphate reductase -
JY395_RS02300 (JY395_02295) 472914..474557 - 1644 WP_215230541.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10903.70 Da        Isoelectric Point: 10.1988

>T195165 WP_215230539.1 NZ_CP071063:469519-469803 [Enterobacter mori]
MTYELAFDPRALKEWSKLGETVKDHFKKKLADVLVNPRVESARLHGLPDCYKIKLRSQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Download         Length: 285 bp

>T195165 NZ_CP094339:4213979-4214131 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT195165 WP_008501400.1 NZ_CP071063:469287-469529 [Enterobacter mori]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT195165 NZ_CP094339:c4213930-4213873 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References