Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 61861..62523 Replicon chromosome
Accession NZ_CP071063
Organism Enterobacter mori strain 08-091

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JY395_RS00305 Protein ID WP_215230450.1
Coordinates 62125..62523 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JY395_RS00300 Protein ID WP_109081969.1
Coordinates 61861..62121 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY395_RS00275 (JY395_00275) 57076..58197 - 1122 WP_215230448.1 efflux RND transporter periplasmic adaptor subunit -
JY395_RS00280 (JY395_00280) 58346..58915 - 570 WP_010426497.1 TetR/AcrR family transcriptional regulator -
JY395_RS00285 (JY395_00285) 59102..59521 + 420 WP_042714400.1 GNAT family N-acetyltransferase -
JY395_RS00290 (JY395_00290) 59518..60165 - 648 WP_215230449.1 TetR/AcrR family transcriptional regulator -
JY395_RS00295 (JY395_00295) 60244..61743 + 1500 WP_244999832.1 MDR family MFS transporter -
JY395_RS00300 (JY395_00300) 61861..62121 + 261 WP_109081969.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JY395_RS00305 (JY395_00305) 62125..62523 + 399 WP_215230450.1 type II toxin-antitoxin system VapC family toxin Toxin
JY395_RS00310 (JY395_00310) 62712..63512 + 801 WP_109081970.1 lipoprotein NlpA -
JY395_RS00315 (JY395_00315) 63608..64387 + 780 WP_215230451.1 MBL fold metallo-hydrolase -
JY395_RS00320 (JY395_00320) 64413..65366 + 954 WP_215230452.1 helix-turn-helix domain-containing protein -
JY395_RS00325 (JY395_00325) 65395..66483 - 1089 WP_042714408.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14784.03 Da        Isoelectric Point: 6.3267

>T195164 WP_215230450.1 NZ_CP071063:62125-62523 [Enterobacter mori]
MLHMLDTNIVSHLVRQHPEVLNQYSRIAPEKMCISSVTEAELLYGVAKKQNNQLHKTILEFLKTITICDWDSEAAAAYGE
LRAVMEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFGMVQDLRVEDWTTAA

Download         Length: 399 bp

>T195164 NZ_CP094339:c3944486-3944088 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10104.44 Da        Isoelectric Point: 9.6539

>AT195164 WP_109081969.1 NZ_CP071063:61861-62121 [Enterobacter mori]
MERTVKLIKKGRKQAVVLPAEFAFDTESVYIRRDDEGNIVLTARSEKERHRDNFLRLLKQTHVPDSFLSKEERNQSYSTR
DPLEGL

Download         Length: 261 bp

>AT195164 NZ_CP094339:c3944782-3944489 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References