Detailed information of TA system TA195163

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4913387..4914975
• Replicon: chromosome
• Accession: NZ_CP071062
• Organism: Dickeya solani strain IPO2019

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2K8W078
• Locus tag: JYR06_RS21385
• Protein ID: WP_022635525.1
• Coordinates: 4913656..4914975 (+)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A2K8W0B1
• Locus tag: JYR06_RS21380
• Protein ID: WP_022635524.1
• Coordinates: 4913387..4913656 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYR06_RS21355	4908705..4909316	-	612	WP_022635519.1	NAD(P)-dependent oxidoreductase	-
JYR06_RS21360	4909458..4909844	+	387	WP_022635520.1	helix-turn-helix transcriptional regulator	-
JYR06_RS21365	4909943..4911028	-	1086	WP_022635521.1	4-hydroxyphenylpyruvate dioxygenase	-
JYR06_RS21370	4911343..4912116	+	774	WP_022635522.1	MBL fold metallo-hydrolase	-
JYR06_RS21375	4912160..4913116	+	957	WP_026595316.1	helix-turn-helix domain-containing protein	-
JYR06_RS21380	4913387..4913656	+	270	WP_022635524.1	helix-turn-helix domain-containing protein	Antitoxin
JYR06_RS21385	4913656..4914975	+	1320	WP_022635525.1	type II toxin-antitoxin system HipA family toxin	Toxin
JYR06_RS21390	4915047..4916411	-	1365	WP_022635526.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
JYR06_RS21395	4916527..4918158	-	1632	WP_022635527.1	membrane protein insertase YidC	-
JYR06_RS21400	4918161..4918418	-	258	WP_071598660.1	membrane protein insertion efficiency factor YidD	-
JYR06_RS21405	4918382..4918741	-	360	WP_022635528.1	ribonuclease P protein component	-
JYR06_RS21410	4918760..4918900	-	141	WP_004093983.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49161.32 Da
• Isoelectric Point: 6.6616

>T195163 WP_022635525.1 NZ_CP071062:4913656-4914975 [Dickeya solani]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLELPGSRPLSLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVTRHQ
ADSTQPFDLLAKVGQDSVGALQLVPQGTAVGDIKQIEYKTLSEQQLENILAGYLSDAPLGMIDTEEDFRISIAGAQEKTA
LLYLDGSWCLPLNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLSVPHCFMITAGKIKALAVERFDRK
YASDGRWIMRLPQEDFCQVLNVPSARKYENHGGPGISAIMSVLLGAIEPERDRYTFMKAQVLFWLLAATDGHAKNFSLFI
EFEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSKGKKYAIEQIFPRHFFQTAKVVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSSRLTTGWE

Nucleotide

• Length: 1320 bp

>T195163 NZ_CP094339:3742390-3742608 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9950.26 Da
• Isoelectric Point: 10.0983

>AT195163 WP_022635524.1 NZ_CP071062:4913387-4913656 [Dickeya solani]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTITPRNAHAANNEASV
ATSAWKEEW

Nucleotide

• Length: 270 bp

>AT195163 NZ_CP094339:3741990-3742364 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A2K8W078

Antitoxin

• AlphaFold DB: A0A2K8W0B1