Detailed information of TA system TA195162

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3764473..3766313
• Replicon: chromosome
• Accession: NZ_CP071062
• Organism: Dickeya solani strain IPO2019

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2K8VX87
• Locus tag: JYR06_RS16510
• Protein ID: WP_022634631.1
• Coordinates: 3764967..3766313 (-)
• Length: 449 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JYR06_RS16505
• Protein ID: WP_099048985.1
• Coordinates: 3764473..3764856 (-)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYR06_RS16480	3759790..3760629	-	840	WP_022634625.1	MurR/RpiR family transcriptional regulator	-
JYR06_RS16485	3760804..3762393	+	1590	WP_022634626.1	gamma-glutamyltransferase family protein	-
JYR06_RS16490	3762438..3762635	+	198	WP_022634627.1	oxalurate catabolism protein HpxX	-
JYR06_RS16495	3762632..3764044	+	1413	WP_022634628.1	AtzE family amidohydrolase	-
JYR06_RS16500	3764041..3764421	+	381	WP_022634629.1	oxalurate catabolism protein HpxZ	-
JYR06_RS16505	3764473..3764856	-	384	WP_099048985.1	helix-turn-helix domain-containing protein	Antitoxin
JYR06_RS16510	3764967..3766313	-	1347	WP_022634631.1	type II toxin-antitoxin system HipA family toxin	Toxin
JYR06_RS16515	3766586..3767533	-	948	WP_022634632.1	allantoinase PuuE	-
JYR06_RS16520	3767577..3768314	-	738	WP_022634633.1	allantoin racemase	-
JYR06_RS16525	3768311..3769054	-	744	WP_022634634.1	GntR family transcriptional regulator	-
JYR06_RS16530	3769207..3770691	+	1485	WP_022634635.1	NCS1 family nucleobase:cation symporter-1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (165-392)

Antitoxin

• Cro/C1-type helix-turn-helix domain (51-104)

Sequences

Toxin

Protein

• Length: 449 a.a.
• Molecular weight: 50541.28 Da
• Isoelectric Point: 4.9663

>T195162 WP_022634631.1 NZ_CP071062:c3766313-3764967 [Dickeya solani]
MERLTVQAFIDNAWQDIAEIGFPESDQDNYLLTRLDYASDYGLDYMDCDDHHAVSVNYPVRIFFDDGGELGWMRFLDDIM
PAGASRKYWVDHLDLSGLPAPLQNYVLLRHATIAPVGNLRIKESIPVRHEGATRFFSVEDVKNRAADFLDYAQQRGAAAG
GATGAGGEAPKLLLRCNADDRVWIDTWQDKTDCRDTAYLVKFPRGQRSEIDCDILRAEFHYYHELAAMGFDTIPVAGMRL
EEGRHYPSLWLPRFDIEFPGDGRVKRYGMESVYSLLRAGPGSALRHDQTIRAVIAKIASSHTVSVEGKPFDQAAFVIEWV
RRDVLNIAFGNSDNHGRNTAFLKDEQGIRLAPIYDFAPMKADPAGIARATKWPEPLEIGGDYQFEWIAEQLSDMLPPALL
MERLRETAVQLVGLKARLQARGVPESILTMPSIGFDYLPEKLQRWGLL

Nucleotide

• Length: 1347 bp

>T195162 NZ_CP094339:c3713268-3712966 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATTGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 13731.06 Da
• Isoelectric Point: 10.8242

>AT195162 WP_099048985.1 NZ_CP071062:c3764856-3764473 [Dickeya solani]
MLRPPVIAVAETADIPKARASKNSRPLNASERQSAMQSIIRRMMVGEISQGNALRELRLSVLGLKQDAYASLVGVSRKTL
SEIENDKGNYTADIINKVFKPFGLKMGLIPVSPSLLAEILATAPASR

Nucleotide

• Length: 384 bp

>AT195162 NZ_CP094339:c3712930-3712589 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Structures

Toxin

• AlphaFold DB: A0A2K8VX87