Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2716813..2717408 Replicon chromosome
Accession NZ_CP071062
Organism Dickeya solani strain IPO2019

Toxin (Protein)


Gene name doc Uniprot ID E0SEA8
Locus tag JYR06_RS12000 Protein ID WP_013318177.1
Coordinates 2716813..2717190 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2K8VUJ6
Locus tag JYR06_RS12005 Protein ID WP_022633800.1
Coordinates 2717187..2717408 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYR06_RS11980 2712479..2712745 + 267 WP_022633797.1 hypothetical protein -
JYR06_RS11985 2712977..2713159 + 183 WP_072142890.1 hypothetical protein -
JYR06_RS11990 2713241..2715007 - 1767 WP_022633798.1 ATP-binding protein -
JYR06_RS11995 2714997..2716175 - 1179 WP_022633799.1 hypothetical protein -
JYR06_RS12000 2716813..2717190 - 378 WP_013318177.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JYR06_RS12005 2717187..2717408 - 222 WP_022633800.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JYR06_RS12010 2717549..2718697 - 1149 WP_022633801.1 L-threonine dehydrogenase -
JYR06_RS12015 2718979..2719539 + 561 WP_026594485.1 NUDIX domain-containing protein -
JYR06_RS12020 2719611..2720288 - 678 WP_022633803.1 respiratory nitrate reductase subunit gamma -
JYR06_RS12025 2720288..2721007 - 720 WP_022633804.1 nitrate reductase molybdenum cofactor assembly chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2708369..2717408 9039


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14320.39 Da        Isoelectric Point: 4.9309

>T195161 WP_013318177.1 NZ_CP071062:c2717190-2716813 [Dickeya solani]
MKWVSAQDVIDFHDRILQVLPGVVGMADPGRAEELIYRVQNRLYYEGVTELFELAATYWVTIARGHIFNDGNKRTAFFVT
MTFLRRNGILIVDNDNSLEELTIKAATGECLVSELAEQLRQRVEK

Download         Length: 378 bp

>T195161 NZ_CP094339:c3076059-3075685 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8207.33 Da        Isoelectric Point: 7.2021

>AT195161 WP_022633800.1 NZ_CP071062:c2717408-2717187 [Dickeya solani]
MKTYTITEARQNIATVIDTAASGEPVEIKRRDGTSAVLIPKAEFEAYQKARLDAEFDFIMQRHGHTIKALADR

Download         Length: 222 bp

>AT195161 NZ_CP094339:c3076483-3076106 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCACCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGAAGCTGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCACCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0SEA8

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8VUJ6

References