Detailed information of TA system TA195151

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1882277..1882830
• Replicon: chromosome
• Accession: NZ_CP071062
• Organism: Dickeya solani strain IPO2019

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: JYR06_RS08365
• Protein ID: WP_022633101.1
• Coordinates: 1882516..1882830 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A2K8W593
• Locus tag: JYR06_RS08360
• Protein ID: WP_022633100.1
• Coordinates: 1882277..1882513 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYR06_RS08340	1877853..1879502	+	1650	WP_022633097.1	hypothetical protein	-
JYR06_RS08345	1879863..1880264	-	402	WP_023637748.1	hypothetical protein	-
JYR06_RS08350	1880328..1880621	-	294	WP_146053334.1	hypothetical protein	-
JYR06_RS08355	1881012..1881956	+	945	WP_022633099.1	DUF1738 domain-containing protein	-
JYR06_RS08360	1882277..1882513	+	237	WP_022633100.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
JYR06_RS08365	1882516..1882830	+	315	WP_022633101.1	CcdB family protein	Toxin
JYR06_RS08370	1882827..1883084	-	258	WP_022633102.1	hypothetical protein	-
JYR06_RS08375	1883260..1884567	-	1308	WP_022633103.1	type II toxin-antitoxin system HipA family toxin	-
JYR06_RS08380	1884567..1884974	-	408	WP_071598628.1	helix-turn-helix transcriptional regulator	-
JYR06_RS08385	1885357..1886103	-	747	WP_022633104.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	hcp	1873294..1921672	48378

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11459.38 Da
• Isoelectric Point: 7.9859

>T195151 WP_022633101.1 NZ_CP071062:1882516-1882830 [Dickeya solani]
MQFTVYGNTGKSAVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGI

Nucleotide

• Length: 315 bp

>T195151 NZ_CP094339:1929099-1929350 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9020.06 Da
• Isoelectric Point: 6.2206

>AT195151 WP_022633100.1 NZ_CP071062:1882277-1882513 [Dickeya solani]
MTAKQRNTQSVTMTVERALLVRAREAGINLSAILTTALDAELRHHEAKKWQEENREAIDALNRFHDENGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT195151 NZ_CP094339:1929347-1929601 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A2K8W593