Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1222470..1223095 Replicon chromosome
Accession NZ_CP071062
Organism Dickeya solani strain IPO2019

Toxin (Protein)


Gene name Hha Uniprot ID A0A2K8W3K4
Locus tag JYR06_RS05580 Protein ID WP_022632574.1
Coordinates 1222470..1222673 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2K8W3I1
Locus tag JYR06_RS05585 Protein ID WP_022632575.1
Coordinates 1222727..1223095 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYR06_RS05550 1218110..1218448 + 339 WP_002208627.1 P-II family nitrogen regulator -
JYR06_RS05555 1218491..1219783 + 1293 WP_022632570.1 ammonium transporter AmtB -
JYR06_RS05560 1219879..1220742 - 864 WP_022632571.1 acyl-CoA thioesterase II -
JYR06_RS05565 1220994..1221551 + 558 WP_022632572.1 YbaY family lipoprotein -
JYR06_RS05570 1221580..1221909 - 330 WP_022632573.1 MGMT family protein -
JYR06_RS05580 1222470..1222673 - 204 WP_022632574.1 hemolysin expression modulator Hha Toxin
JYR06_RS05585 1222727..1223095 - 369 WP_022632575.1 Hha toxicity modulator TomB Antitoxin
JYR06_RS05590 1223603..1223746 - 144 WP_022632576.1 type B 50S ribosomal protein L36 -
JYR06_RS05595 1223762..1224013 - 252 WP_022632577.1 type B 50S ribosomal protein L31 -
JYR06_RS05600 1224190..1227336 - 3147 WP_022632578.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8161.52 Da        Isoelectric Point: 8.8580

>T195148 WP_022632574.1 NZ_CP071062:c1222673-1222470 [Dickeya solani]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T195148 NZ_CP094339:708627-709010 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14223.06 Da        Isoelectric Point: 5.1663

>AT195148 WP_022632575.1 NZ_CP071062:c1223095-1222727 [Dickeya solani]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSHGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDTELRKWQKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT195148 NZ_CP094339:708169-708537 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W3K4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W3I1

References