Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 598193..598719 Replicon chromosome
Accession NZ_CP071062
Organism Dickeya solani strain IPO2019

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2K8W1W4
Locus tag JYR06_RS02790 Protein ID WP_022632051.1
Coordinates 598193..598498 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2K8W1V7
Locus tag JYR06_RS02795 Protein ID WP_022632052.1
Coordinates 598501..598719 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYR06_RS02770 593421..593818 + 398 Protein_537 DUF3577 domain-containing protein -
JYR06_RS02775 593934..595205 + 1272 WP_022632048.1 hypothetical protein -
JYR06_RS02780 595209..595775 + 567 WP_024103901.1 hypothetical protein -
JYR06_RS02785 595763..597703 + 1941 WP_022632050.1 hypothetical protein -
JYR06_RS02790 598193..598498 - 306 WP_022632051.1 type II toxin-antitoxin system toxin CcdB Toxin
JYR06_RS02795 598501..598719 - 219 WP_022632052.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
JYR06_RS02800 598778..599521 - 744 WP_022632053.1 hypothetical protein -
JYR06_RS02805 600424..600774 - 351 WP_013316250.1 hypothetical protein -
JYR06_RS02810 600897..601085 + 189 WP_033111580.1 hypothetical protein -
JYR06_RS02815 601225..602484 - 1260 WP_022632055.1 integrase arm-type DNA-binding domain-containing protein -
JYR06_RS02825 602882..603457 - 576 WP_022632056.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 592342..602661 10319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11779.68 Da        Isoelectric Point: 4.8837

>T195146 WP_022632051.1 NZ_CP071062:c598498-598193 [Dickeya solani]
MQFIVYEYKRASHYKMFVDVQSDIVETPKRRMVIPLIEAHHLSEKVNKTLFPKIRIDGEDYRLMTTELSSVPVEVMGEVI
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T195146 NZ_CP094339:178089-178196 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8109.02 Da        Isoelectric Point: 5.8316

>AT195146 WP_022632052.1 NZ_CP071062:c598719-598501 [Dickeya solani]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENSEGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT195146 NZ_CP094339:c178041-177975 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W1W4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W1V7

References