Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 592585..593369 Replicon chromosome
Accession NZ_CP071062
Organism Dickeya solani strain IPO2019

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag JYR06_RS02765 Protein ID WP_022632047.1
Coordinates 592875..593369 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A2K8W1V4
Locus tag JYR06_RS02760 Protein ID WP_022632046.1
Coordinates 592585..592878 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYR06_RS02740 588411..588863 + 453 WP_022632042.1 hypothetical protein -
JYR06_RS02745 588906..589202 + 297 WP_022632043.1 hypothetical protein -
JYR06_RS02750 589230..589937 + 708 WP_022632044.1 SDR family oxidoreductase -
JYR06_RS02755 590929..592180 - 1252 Protein_534 tyrosine-type recombinase/integrase -
JYR06_RS02760 592585..592878 + 294 WP_022632046.1 DUF1778 domain-containing protein Antitoxin
JYR06_RS02765 592875..593369 + 495 WP_022632047.1 GNAT family N-acetyltransferase Toxin
JYR06_RS02770 593421..593818 + 398 Protein_537 DUF3577 domain-containing protein -
JYR06_RS02775 593934..595205 + 1272 WP_022632048.1 hypothetical protein -
JYR06_RS02780 595209..595775 + 567 WP_024103901.1 hypothetical protein -
JYR06_RS02785 595763..597703 + 1941 WP_022632050.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 592342..602661 10319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-143)

Antitoxin

Vibrio phage ICP1, Orf50

(5-95)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17639.41 Da        Isoelectric Point: 6.8524

>T195145 WP_022632047.1 NZ_CP071062:592875-593369 [Dickeya solani]
MISAPEPLHAEHVLSSFCCGVESMDNWLKQRAMKNQVTGASRTFVSCDDSRVLAYYSLASSAVATTAAPGRFRRNMPDPI
PVVVLGRLAVDTSLHGQGVGRALVRDAGLRVIQVADTIGIRGMLVHALSDEARDFYLRVGFEPSPIDPMILMVTLGDLVG
SLSI

Download         Length: 495 bp

>T195145 NZ_CP094339:177607-177714 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10942.53 Da        Isoelectric Point: 9.8078

>AT195145 WP_022632046.1 NZ_CP071062:592585-592878 [Dickeya solani]
MPVTNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLARLDQAPEPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp

>AT195145 NZ_CP094339:c177550-177493 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W1V4

References