Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1095450..1096240 Replicon chromosome
Accession NZ_CP071057
Organism Marinicauda algicola strain RMAR8-3

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag JW792_RS05450 Protein ID WP_135996650.1
Coordinates 1095722..1096240 (+) Length 173 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag JW792_RS05445 Protein ID WP_135996652.1
Coordinates 1095450..1095725 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW792_RS05415 1090692..1091093 - 402 WP_135996659.1 hypothetical protein -
JW792_RS05420 1091090..1092424 - 1335 WP_135996658.1 recombinase family protein -
JW792_RS05425 1092421..1092801 - 381 WP_206340905.1 DUF2924 domain-containing protein -
JW792_RS05430 1092785..1093975 + 1191 WP_206340906.1 AAA family ATPase -
JW792_RS05435 1094488..1094946 + 459 WP_206340949.1 hypothetical protein -
JW792_RS05440 1094943..1095395 + 453 WP_135996654.1 hypothetical protein -
JW792_RS05445 1095450..1095725 + 276 WP_135996652.1 DUF1778 domain-containing protein Antitoxin
JW792_RS05450 1095722..1096240 + 519 WP_135996650.1 GNAT family N-acetyltransferase Toxin
JW792_RS05455 1096712..1098088 + 1377 WP_135996648.1 site-specific DNA-methyltransferase -
JW792_RS05460 1098090..1099271 + 1182 WP_135996646.1 DNA cytosine methyltransferase -
JW792_RS05465 1099284..1099556 + 273 WP_206340907.1 DUF3489 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(49-151)

Antitoxin

Vibrio phage ICP1, Orf50

(4-89)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 18806.43 Da        Isoelectric Point: 6.7533

>T195144 WP_135996650.1 NZ_CP071057:1095722-1096240 [Marinicauda algicola]
VTAENQSFSAVQKLDASHDVDGFDCGKEPLDRFLQRHALVNQKAGSAQTYVVCRGEQRVAGYYSLAVGAVEHAEAPGRVS
KGLARHPIPVMLLARLAIDRAEQGKGLGKALLKDALLRTAQAADIAGIRALLVHAKDDEARAWYEQFDFEPSPTDPYHLF
LLMKDLRALLGE

Download         Length: 519 bp

>T195144 NZ_CP094334:c13221-13072 [Salmonella enterica subsp. enterica]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10387.97 Da        Isoelectric Point: 7.2062

>AT195144 WP_135996652.1 NZ_CP071057:1095450-1095725 [Marinicauda algicola]
MPVAEAKSERIEVRTTPTMKALLQRAATFSHKNVTEFLLEAGIHAAEEALVDRRMFRLDDAQWQAFQDVLDRPVQSKPRL
ARLLAEKSVLE

Download         Length: 276 bp

>AT195144 NZ_CP094334:13266-13325 [Salmonella enterica subsp. enterica]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References