Detailed information of TA system TA195141

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 2800702..2801267
• Replicon: chromosome
• Accession: NZ_CP071044
• Organism: Streptomyces sp. CA-256286

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: JHY03_RS12295
• Protein ID: WP_164357071.1
• Coordinates: 2800702..2801070 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: JHY03_RS12300
• Protein ID: WP_031125199.1
• Coordinates: 2801070..2801267 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JHY03_RS12280	2796734..2797522	-	789	WP_031125196.1	hypothetical protein	-
JHY03_RS12285	2797661..2798305	-	645	WP_015608848.1	helix-turn-helix domain-containing protein	-
JHY03_RS12290	2798748..2800532	-	1785	WP_015608852.1	DEAD/DEAH box helicase	-
JHY03_RS12295	2800702..2801070	-	369	WP_164357071.1	Fic family protein	Toxin
JHY03_RS12300	2801070..2801267	-	198	WP_031125199.1	hypothetical protein	Antitoxin
JHY03_RS12305	2801304..2802911	-	1608	WP_031125200.1	MFS transporter	-
JHY03_RS12315	2803234..2803986	-	753	WP_207564208.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (7-80)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13568.48 Da
• Isoelectric Point: 5.1084

>T195141 WP_164357071.1 NZ_CP071044:c2801070-2800702 [Streptomyces sp. CA-256286]
MQYLNLSELLSLAQRLGAAEVRDYGLLESALARPQASVFGQDAYPDVWQKAAALMESLARNHGLVDGNKRIAWYATWVFL
HLNGHPLDPRFDADEAERFVLAVCQGALDMPKIAEQLPGFAR

Nucleotide

• Length: 369 bp

>T195141 NZ_CP094332:c4763276-4762965 [Salmonella enterica subsp. enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7284.14 Da
• Isoelectric Point: 5.0632

>AT195141 WP_031125199.1 NZ_CP071044:c2801267-2801070 [Streptomyces sp. CA-256286]
MAGLNLRFTEEELDSLRSRAEAEGKSMQAFAHDAVITAMNEHARLFNEAADHVLKASEELNRRLA

Nucleotide

• Length: 198 bp

>AT195141 NZ_CP094332:c4762964-4762674 [Salmonella enterica subsp. enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA