195135

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 258743..259265 Replicon plasmid pKP-1PI_HIB-FIB
Accession NZ_CP071028
Organism Klebsiella pneumoniae strain KP-1Pi

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag HZC88_RS27580 Protein ID WP_004181778.1
Coordinates 258981..259265 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5Q9LM53
Locus tag HZC88_RS27575 Protein ID WP_025368601.1
Coordinates 258743..258991 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZC88_RS27555 (HZC88_27470) 253952..254773 - 822 WP_004026535.1 hypothetical protein -
HZC88_RS27560 (HZC88_27475) 254835..255188 - 354 WP_004181774.1 hypothetical protein -
HZC88_RS27565 (HZC88_27480) 255333..256319 - 987 WP_025368599.1 hypothetical protein -
HZC88_RS27570 (HZC88_27485) 256653..258452 - 1800 WP_025368600.1 ATP-dependent helicase -
HZC88_RS27575 (HZC88_27490) 258743..258991 + 249 WP_025368601.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HZC88_RS27580 (HZC88_27495) 258981..259265 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZC88_RS27585 (HZC88_27500) 259495..260721 + 1227 WP_025368602.1 RNA-guided endonuclease TnpB family protein -
HZC88_RS27590 (HZC88_27505) 261007..261432 - 426 WP_040120489.1 IS200/IS605 family transposase -
HZC88_RS27595 (HZC88_27510) 261469..262695 + 1227 WP_025368604.1 RNA-guided endonuclease TnpB family protein -
HZC88_RS27600 (HZC88_27515) 262761..263887 - 1127 Protein_287 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / mph(A) / sul1 / qacE / dfrA5 / mph(E) / msr(E) / armA / sul2 / blaCTX-M-15 rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..340568 340568


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T195135 WP_004181778.1 NZ_CP071028:258981-259265 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T195135 NZ_CP094332:2401906-2402190 [Salmonella enterica subsp. enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.12 Da        Isoelectric Point: 3.8206

>AT195135 WP_025368601.1 NZ_CP071028:258743-258991 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT195135 NZ_CP094332:2401668-2401916 [Salmonella enterica subsp. enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LM53

References