Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 36459..37369 Replicon plasmid pKP-1PI_HIB-FIB
Accession NZ_CP071028
Organism Klebsiella pneumoniae strain KP-1Pi

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag HZC88_RS26410 Protein ID WP_004026354.1
Coordinates 36899..37369 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag HZC88_RS26405 Protein ID WP_004181895.1
Coordinates 36459..36902 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZC88_RS26390 (HZC88_26315) 33092..34579 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
HZC88_RS26395 (HZC88_26320) 34665..35087 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
HZC88_RS26400 (HZC88_26325) 35087..36358 + 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
HZC88_RS26405 (HZC88_26330) 36459..36902 + 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
HZC88_RS26410 (HZC88_26335) 36899..37369 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
HZC88_RS26415 (HZC88_26340) 37479..37739 - 261 WP_004026352.1 hypothetical protein -
HZC88_RS26420 (HZC88_26345) 38461..38619 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
HZC88_RS26425 (HZC88_26350) 39222..40196 + 975 WP_058842863.1 hypothetical protein -
HZC88_RS28960 40180..40302 + 123 WP_257183836.1 hypothetical protein -
HZC88_RS26430 (HZC88_26355) 40394..40771 - 378 WP_029884711.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / mph(A) / sul1 / qacE / dfrA5 / mph(E) / msr(E) / armA / sul2 / blaCTX-M-15 rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..340568 340568


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T195133 WP_004026354.1 NZ_CP071028:36899-37369 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T195133 NZ_CP094332:c996596-996069 [Salmonella enterica subsp. enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT195133 WP_004181895.1 NZ_CP071028:36459-36902 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT195133 NZ_CP094332:c996883-996593 [Salmonella enterica subsp. enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References