Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4798484..4799000 Replicon chromosome
Accession NZ_CP071027
Organism Klebsiella pneumoniae strain KP-1Pi

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag HZC88_RS23420 Protein ID WP_009486548.1
Coordinates 4798484..4798768 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HZC88_RS23425 Protein ID WP_002886901.1
Coordinates 4798758..4799000 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZC88_RS23395 (4793901) 4793901..4794164 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
HZC88_RS23400 (4794294) 4794294..4794467 + 174 WP_032433782.1 hypothetical protein -
HZC88_RS23405 (4794470) 4794470..4795213 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HZC88_RS23410 (4795570) 4795570..4797708 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HZC88_RS23415 (4798016) 4798016..4798480 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HZC88_RS23420 (4798484) 4798484..4798768 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZC88_RS23425 (4798758) 4798758..4799000 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HZC88_RS23430 (4799078) 4799078..4800988 - 1911 WP_009486549.1 PRD domain-containing protein -
HZC88_RS23435 (4801011) 4801011..4802165 - 1155 WP_002886900.1 lactonase family protein -
HZC88_RS23440 (4802232) 4802232..4802972 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T195130 WP_009486548.1 NZ_CP071027:c4798768-4798484 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T195130 NZ_CP094332:365060-365335 [Salmonella enterica subsp. enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT195130 WP_002886901.1 NZ_CP071027:c4799000-4798758 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT195130 NZ_CP094332:364797-365057 [Salmonella enterica subsp. enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References