Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2693014..2694602 Replicon chromosome
Accession NZ_CP071027
Organism Klebsiella pneumoniae strain KP-1Pi

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag HZC88_RS13160 Protein ID WP_002904792.1
Coordinates 2693014..2694336 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag HZC88_RS13165 Protein ID WP_002904790.1
Coordinates 2694336..2694602 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZC88_RS13145 (2688070) 2688070..2690571 + 2502 WP_032433099.1 fimbria/pilus outer membrane usher protein -
HZC88_RS13150 (2690559) 2690559..2691563 + 1005 WP_032433097.1 fimbrial protein -
HZC88_RS13155 (2691705) 2691705..2692997 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HZC88_RS13160 (2693014) 2693014..2694336 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
HZC88_RS13165 (2694336) 2694336..2694602 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HZC88_RS13170 (2694988) 2694988..2695314 - 327 WP_002904788.1 hydroxyisourate hydrolase -
HZC88_RS13175 (2695311) 2695311..2695811 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HZC88_RS13180 (2695789) 2695789..2697168 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
HZC88_RS13185 (2697514) 2697514..2698668 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
HZC88_RS13190 (2698649) 2698649..2699572 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T195127 WP_002904792.1 NZ_CP071027:c2694336-2693014 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T195127 NZ_CP094325:66237-66653 [Edwardsiella anguillarum]
GTGAACAAGACCTACATGCTGGACACCAATATCTGCTCATTCATCATGCGCGAGCAGCCGGATGTGGTACTGAAGCATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGCATTGTGGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAAGCCTCGCCGCGCCACGTTCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGCTGTCACTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCATGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT195127 WP_002904790.1 NZ_CP071027:c2694602-2694336 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT195127 NZ_CP094325:66010-66240 [Edwardsiella anguillarum]
ATGAGAACCGTATCGATATTTAAAAATGGCAATAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGTATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCACCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References