Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1452133..1452776 Replicon chromosome
Accession NZ_CP071027
Organism Klebsiella pneumoniae strain KP-1Pi

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag HZC88_RS07150 Protein ID WP_032433387.1
Coordinates 1452360..1452776 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag HZC88_RS07145 Protein ID WP_001261276.1
Coordinates 1452133..1452363 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZC88_RS07130 (1447155) 1447155..1448242 + 1088 Protein_1394 transcriptional repressor PifC -
HZC88_RS07135 (1448245) 1448245..1450485 + 2241 WP_045326788.1 P-loop NTPase fold protein -
HZC88_RS07140 (1451013) 1451013..1451828 - 816 WP_032433388.1 hypothetical protein -
HZC88_RS07145 (1452133) 1452133..1452363 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HZC88_RS07150 (1452360) 1452360..1452776 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
HZC88_RS07155 (1452932) 1452932..1453912 + 981 WP_032433385.1 hypothetical protein -
HZC88_RS07160 (1454107) 1454107..1455678 - 1572 WP_032433383.1 AAA family ATPase -
HZC88_RS07165 (1455997) 1455997..1456245 + 249 WP_032433382.1 hypothetical protein -
HZC88_RS07170 (1456304) 1456304..1456822 + 519 WP_045326794.1 hypothetical protein -
HZC88_RS07175 (1456853) 1456853..1457344 + 492 WP_032433378.1 hypothetical protein -
HZC88_RS07180 (1457404) 1457404..1457607 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1436769..1482786 46017


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T195117 WP_032433387.1 NZ_CP071027:1452360-1452776 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

>T195117 NZ_CP094323:c1111501-1111298 [Edwardsiella anguillarum]
ATGACCAAGATCGATTATCTGATGAAGCTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAACTAGAAATTTTTTATTCTGCTGCAGATCATCGACTAGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCGGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT195117 WP_001261276.1 NZ_CP071027:1452133-1452363 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT195117 NZ_CP094323:c1111890-1111522 [Edwardsiella anguillarum]
ATGGATGAGTATACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAACCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCGTCGCACAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATACTGGATGATTATCTG
GATGAAACCTACGCCCTGTTTGGTGCCTATAGCGTCAGTGAAACGGCGCTCAGACACTGGTTGCGTACCAAACGCCGTGT
GGCATACTGCCTGGCGCATGAAAAGCGCAATGCGGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References