Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 834253..834910 Replicon chromosome
Accession NZ_CP071027
Organism Klebsiella pneumoniae strain KP-1Pi

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HZC88_RS04175 Protein ID WP_002916310.1
Coordinates 834500..834910 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HZC88_RS04170 Protein ID WP_002916312.1
Coordinates 834253..834519 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZC88_RS04145 (829409) 829409..830842 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
HZC88_RS04150 (830961) 830961..831689 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HZC88_RS04155 (831739) 831739..832050 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HZC88_RS04160 (832214) 832214..832873 + 660 WP_002916317.1 hemolysin III family protein -
HZC88_RS04165 (833024) 833024..834007 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HZC88_RS04170 (834253) 834253..834519 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HZC88_RS04175 (834500) 834500..834910 + 411 WP_002916310.1 protein YgfX Toxin
HZC88_RS04180 (834917) 834917..835438 - 522 WP_004144730.1 flavodoxin FldB -
HZC88_RS04185 (835539) 835539..836435 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HZC88_RS04190 (836458) 836458..837171 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HZC88_RS04195 (837177) 837177..838910 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T195116 WP_002916310.1 NZ_CP071027:834500-834910 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T195116 NZ_CP094322:c3404558-3404142 [Edwardsiella anguillarum]
GTGGTCCTTTGGCGCTGTAACGTTCACGTCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCACGGCGCGCTGGTTTT
GGCGATCCTGCTGGCGCCCTGGCCGGAAAACTACAGCGCATTCTGGCTGGTTCTGCTGGTGGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGTCGGATTGCGCGTAACCGCGGTGAGCTGCAGCTGCTGGCGCCGCAGGTGTGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGGCGCCCCTGGGTTAGCGATCTGGGGGCGCTGCTGATTCTGCAGAGTACCCATGGTGTACCGTG
CCGCCGCCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGAGAAGAGTGGGGGCAGCTGCGCCGCACGCTGCTCGATACGG
GCGACGATCGCGCATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT195116 WP_002916312.1 NZ_CP071027:834253-834519 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT195116 NZ_CP094322:c3404805-3404539 [Edwardsiella anguillarum]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGCGAGCTGGATATCGCGATTATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGCCTGCTGGCCTGCGACGATCCTGAGC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGACGACGCTGATCTGGCCCGTATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGTCCTTTGGCGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References