Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3809944..3810725 Replicon chromosome
Accession NZ_CP071025
Organism Enterobacter hormaechei strain RIVM_C010068

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A431SHU0
Locus tag JQL77_RS18115 Protein ID WP_022649378.1
Coordinates 3809944..3810435 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3S0FY21
Locus tag JQL77_RS18120 Protein ID WP_022649379.1
Coordinates 3810432..3810725 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL77_RS18100 3805224..3805676 - 453 WP_022649375.1 hypothetical protein -
JQL77_RS18105 3806191..3808101 + 1911 WP_022649376.1 hypothetical protein -
JQL77_RS18110 3808098..3809792 + 1695 WP_022649377.1 hypothetical protein -
JQL77_RS18115 3809944..3810435 - 492 WP_022649378.1 GNAT family N-acetyltransferase Toxin
JQL77_RS18120 3810432..3810725 - 294 WP_022649379.1 DUF1778 domain-containing protein Antitoxin
JQL77_RS18125 3810827..3812620 - 1794 WP_206215682.1 hybrid sensor histidine kinase/response regulator -
JQL77_RS18130 3812617..3813249 - 633 WP_022649381.1 response regulator transcription factor -
JQL77_RS18135 3813425..3813739 + 315 WP_003862457.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3805224..3813739 8515


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(83-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17469.36 Da        Isoelectric Point: 8.1405

>T195111 WP_022649378.1 NZ_CP071025:c3810435-3809944 [Enterobacter hormaechei]
MISAPVPLRAGHILTPFCCGVDSMDNWLKQRAMKNQASGASRTFVCCGGDSNVLAYYALASSAVTTNTVPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAESIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMVTLGDLV
ASI

Download         Length: 492 bp

>T195111 NZ_CP094321:c3375464-3375048 [Edwardsiella anguillarum]
GTGGTCCTTTGGCGCTGTAACGTTCACGTCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCACGGCGCGCTGGTTTT
GGCGATCCTGCTGGCGCCCTGGCCGGAAAACTACAGCGCATTCTGGCTGGTTCTGCTGGTGGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGTCGGATTGCGCGTAACCGCGGTGAGCTGCAGCTGCTGGCGCCGCAGGTGTGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGGCGCCCCTGGGTTAGCGATCTGGGGGCGCTGCTGATTCTGCAGAGTACCCATGGTGTACCGTG
CCGCCGCCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGAGAAGAGTGGGGGCAGCTGCGCCGCACGCTGCTCGATACGG
GCGACGATCGCGCATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10959.58 Da        Isoelectric Point: 8.6351

>AT195111 WP_022649379.1 NZ_CP071025:c3810725-3810432 [Enterobacter hormaechei]
MPAANTMAVKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLTRLDQAPAPN
AALRKTMQTLAPWEQEK

Download         Length: 294 bp

>AT195111 NZ_CP094321:c3375711-3375445 [Edwardsiella anguillarum]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGCGAGCTGGATATCGCGATTATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGCCTGCTGGCCTGCGACGATCCTGAGC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGACGACGCTGATCTGGCCCGTATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGTCCTTTGGCGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SHU0

Antitoxin

Source ID Structure
AlphaFold DB A0A3S0FY21

References