Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3717006..3717663 Replicon chromosome
Accession NZ_CP071025
Organism Enterobacter hormaechei strain RIVM_C010068

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag JQL77_RS17635 Protein ID WP_022649305.1
Coordinates 3717006..3717416 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag JQL77_RS17640 Protein ID WP_003863437.1
Coordinates 3717397..3717663 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL77_RS17615 3713004..3714737 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
JQL77_RS17620 3714743..3715456 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JQL77_RS17625 3715485..3716381 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
JQL77_RS17630 3716483..3717004 + 522 WP_015571793.1 flavodoxin FldB -
JQL77_RS17635 3717006..3717416 - 411 WP_022649305.1 protein YgfX Toxin
JQL77_RS17640 3717397..3717663 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
JQL77_RS17645 3717958..3718938 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
JQL77_RS17650 3719462..3720121 - 660 WP_022649307.1 hemolysin III family protein -
JQL77_RS17655 3720388..3721119 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T195110 WP_022649305.1 NZ_CP071025:c3717416-3717006 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T195110 NZ_CP094321:c1825701-1825600 [Edwardsiella anguillarum]
GCAAGGCATTCAATGCCTGCATAATGCCAACTTTTAGCGCACGGCTCTCCATAAGAGCCATTCCCCTAGACCTGACACAG
GAATCGTGCCAGGTCTTTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT195110 WP_003863437.1 NZ_CP071025:c3717663-3717397 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT195110 NZ_CP094321:1825598-1825708 [Edwardsiella anguillarum]
ATAAAAAAAGACCTGGCACGATTCCTGTGTCAGGTCTAGGGGAATGGCTCTTATGGAGAGCCGTGCGCTAAAAGTTGGCA
TTATGCAGGCATTGAATGCCTTGCTCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References