Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3450268..3451007 Replicon chromosome
Accession NZ_CP071025
Organism Enterobacter hormaechei strain RIVM_C010068

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag JQL77_RS16375 Protein ID WP_022649088.1
Coordinates 3450627..3451007 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag JQL77_RS16370 Protein ID WP_022649087.1
Coordinates 3450268..3450594 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL77_RS16355 3446162..3448822 - 2661 WP_022649084.1 hypothetical protein -
JQL77_RS16360 3449356..3449775 + 420 Protein_3193 antirestriction protein -
JQL77_RS16365 3449790..3450257 + 468 WP_022649086.1 DNA repair protein RadC -
JQL77_RS16370 3450268..3450594 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JQL77_RS16375 3450627..3451007 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
JQL77_RS16380 3451004..3451231 + 228 WP_022649089.1 hypothetical protein -
JQL77_RS16385 3451623..3451916 + 294 WP_022649090.1 hypothetical protein -
JQL77_RS16390 3452260..3453576 - 1317 WP_022649091.1 amidase -
JQL77_RS16395 3453631..3454926 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3427159..3451916 24757


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T195109 WP_022649088.1 NZ_CP071025:3450627-3451007 [Enterobacter hormaechei]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T195109 NZ_CP094321:c1821639-1821358 [Edwardsiella anguillarum]
ATGACCTATAAACTGAGCTTTGAAAAGCGAGCCCTGAAAGAGTGGAAAAAACTGGCGCCACCGATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTGGAAAACCCACATGTTCCAGCAGCACGCTTAAGTGGGCGCGCTAACCGTTATAAAATAA
AATTACGCTCTTCCGGTTACCGGTTAGTTTATGAAGTCAACGATAGCGAAATTATCCTGCTGGTGATCGCGATCGGTAAA
CGGGCCGATAACGAGGTGTACCAAGCGGCAGACAGTCGTTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT195109 WP_022649087.1 NZ_CP071025:3450268-3450594 [Enterobacter hormaechei]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT195109 NZ_CP094321:c1821880-1821629 [Edwardsiella anguillarum]
ATGGCATACCAAATTCTCACGACCACCGCCGCCAGCATTACCGACCTGAAACGCAATCCAATGGGTACCATTGCTGAAGG
TGACGGCAATGCCGTAGCAATCTTAAACCGCAATGAGCCGGCCTTTTACTGCGTTCCACCGGAACTCTACGCTTACTATC
TGGAGCTGGCTGAAGATGCGGCACTTAATCGTATCGCCGATGAGCGTCTGGAGGACGCTGAGTTTGTCAGCGTAAATATC
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References