Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2276936..2277675 Replicon chromosome
Accession NZ_CP071025
Organism Enterobacter hormaechei strain RIVM_C010068

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag JQL77_RS10975 Protein ID WP_022648141.1
Coordinates 2276936..2277421 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag JQL77_RS10980 Protein ID WP_003857131.1
Coordinates 2277409..2277675 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL77_RS10950 2273092..2274114 + 1023 WP_022648135.1 alpha/beta hydrolase -
JQL77_RS10955 2274210..2274974 + 765 WP_022648136.1 SDR family oxidoreductase -
JQL77_RS10960 2275623..2275904 + 282 Protein_2135 DUF4225 domain-containing protein -
JQL77_RS10965 2275879..2276208 - 330 WP_022648139.1 hypothetical protein -
JQL77_RS10970 2276341..2276910 + 570 WP_022648140.1 hypothetical protein -
JQL77_RS10975 2276936..2277421 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
JQL77_RS10980 2277409..2277675 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
JQL77_RS10985 2277739..2278668 - 930 WP_022648142.1 LysR family transcriptional regulator -
JQL77_RS10990 2278798..2280186 + 1389 WP_022648143.1 MFS transporter -
JQL77_RS10995 2280165..2280722 - 558 WP_022648144.1 OmpH family outer membrane protein -
JQL77_RS11000 2280843..2281979 - 1137 WP_022648145.1 type 1 fimbrial protein -
JQL77_RS11005 2282003..2282527 - 525 WP_087878309.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2254069..2280722 26653


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T195100 WP_022648141.1 NZ_CP071025:c2277421-2276936 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T195100 NZ_CP094319:c1825698-1825597 [Edwardsiella anguillarum]
GCAAGGCATTCAATGCCTGCATAATGCCAACTTTTAGCGCACGGCTCTCCATAAGAGCCATTCCCCTAGACCTGACACAG
GAATCGTGCCAGGTCTTTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT195100 WP_003857131.1 NZ_CP071025:c2277675-2277409 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT195100 NZ_CP094319:1825595-1825705 [Edwardsiella anguillarum]
ATAAAAAAAGACCTGGCACGATTCCTGTGTCAGGTCTAGGGGAATGGCTCTTATGGAGAGCCGTGCGCTAAAAGTTGGCA
TTATGCAGGCATTGAATGCCTTGCTCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References