Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3827148..3827929 Replicon chromosome
Accession NZ_CP071023
Organism Enterobacter hormaechei strain RIVM_C012369

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A431SHU0
Locus tag JQL72_RS18220 Protein ID WP_022649378.1
Coordinates 3827148..3827639 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3S0FY21
Locus tag JQL72_RS18225 Protein ID WP_022649379.1
Coordinates 3827636..3827929 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL72_RS18205 3822428..3822880 - 453 WP_022649375.1 hypothetical protein -
JQL72_RS18210 3823395..3825305 + 1911 WP_022649376.1 hypothetical protein -
JQL72_RS18215 3825302..3826996 + 1695 WP_022649377.1 hypothetical protein -
JQL72_RS18220 3827148..3827639 - 492 WP_022649378.1 GNAT family N-acetyltransferase Toxin
JQL72_RS18225 3827636..3827929 - 294 WP_022649379.1 DUF1778 domain-containing protein Antitoxin
JQL72_RS18230 3828031..3829824 - 1794 WP_022649380.1 hybrid sensor histidine kinase/response regulator -
JQL72_RS18235 3829821..3830453 - 633 WP_022649381.1 response regulator transcription factor -
JQL72_RS18240 3830629..3830943 + 315 WP_003862457.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3822428..3830943 8515


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(83-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17469.36 Da        Isoelectric Point: 8.1405

>T195095 WP_022649378.1 NZ_CP071023:c3827639-3827148 [Enterobacter hormaechei]
MISAPVPLRAGHILTPFCCGVDSMDNWLKQRAMKNQASGASRTFVCCGGDSNVLAYYALASSAVTTNTVPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAESIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMVTLGDLV
ASI

Download         Length: 492 bp

>T195095 NZ_CP094318:20278-20694 [Edwardsiella anguillarum]
GTGAACAAGACCTACATGCTGGACACCAATATCTGCTCATTCATCATGCGCGAGCAGCCGGATGTGGTACTGAAGCATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGCATTGTGGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAAGCCTCGCCGCGCCACGTTCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGCTGTCACTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCATGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10959.58 Da        Isoelectric Point: 8.6351

>AT195095 WP_022649379.1 NZ_CP071023:c3827929-3827636 [Enterobacter hormaechei]
MPAANTMAVKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLTRLDQAPAPN
AALRKTMQTLAPWEQEK

Download         Length: 294 bp

>AT195095 NZ_CP094318:20051-20281 [Edwardsiella anguillarum]
ATGAGAACCGTATCGATATTTAAAAATGGCAATAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGTATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCACCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SHU0

Antitoxin

Source ID Structure
AlphaFold DB A0A3S0FY21

References