Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3734210..3734867 Replicon chromosome
Accession NZ_CP071023
Organism Enterobacter hormaechei strain RIVM_C012369

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag JQL72_RS17740 Protein ID WP_022649305.1
Coordinates 3734210..3734620 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag JQL72_RS17745 Protein ID WP_003863437.1
Coordinates 3734601..3734867 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL72_RS17720 3730208..3731941 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
JQL72_RS17725 3731947..3732660 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JQL72_RS17730 3732689..3733585 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
JQL72_RS17735 3733687..3734208 + 522 WP_015571793.1 flavodoxin FldB -
JQL72_RS17740 3734210..3734620 - 411 WP_022649305.1 protein YgfX Toxin
JQL72_RS17745 3734601..3734867 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
JQL72_RS17750 3735162..3736142 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
JQL72_RS17755 3736666..3737325 - 660 WP_022649307.1 hemolysin III family protein -
JQL72_RS17760 3737592..3738323 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T195094 WP_022649305.1 NZ_CP071023:c3734620-3734210 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T195094 NZ_CP094317:2738735-2738938 [Edwardsiella anguillarum]
ATGACCAAGATCGATTATCTAATGAAGCTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAACTAGAAATTTTTTATTCTGCTGCAGATCATCGACTAGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCGGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT195094 WP_003863437.1 NZ_CP071023:c3734867-3734601 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT195094 NZ_CP094317:2738346-2738714 [Edwardsiella anguillarum]
ATGGATGAGTATACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAACCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCGTCGCACAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATACTGGATGATTATCTG
GATGAAACCTACGCCCTGTTTGGTGCCTATAGCGTCAGTGAAACGGCGCTCAGACACTGGCTGCGTACCAAACGCCGTGT
GGCATACTGCCTGGCGCATGAAAAGCGCAATGCGGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References