Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3454040..3454779 Replicon chromosome
Accession NZ_CP071023
Organism Enterobacter hormaechei strain RIVM_C012369

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag JQL72_RS16395 Protein ID WP_022649088.1
Coordinates 3454399..3454779 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag JQL72_RS16390 Protein ID WP_022649087.1
Coordinates 3454040..3454366 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL72_RS16375 3449934..3452594 - 2661 WP_022649084.1 hypothetical protein -
JQL72_RS16380 3453128..3453547 + 420 Protein_3197 antirestriction protein -
JQL72_RS16385 3453562..3454029 + 468 WP_022649086.1 DNA repair protein RadC -
JQL72_RS16390 3454040..3454366 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JQL72_RS16395 3454399..3454779 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
JQL72_RS16400 3454776..3455003 + 228 WP_022649089.1 hypothetical protein -
JQL72_RS16405 3455395..3455688 + 294 WP_022649090.1 hypothetical protein -
JQL72_RS16410 3456032..3457348 - 1317 WP_206215736.1 amidase -
JQL72_RS16415 3457403..3458698 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3429708..3455688 25980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T195093 WP_022649088.1 NZ_CP071023:3454399-3454779 [Enterobacter hormaechei]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T195093 NZ_CP094317:2016932-2017189 [Edwardsiella anguillarum]
ATGCCAGAGATTGATGCCCTGATGGGGCTAAGCTTTGTGATGTATTTCTTCGACAATCAAACTCACAGTTTGCCGCATGT
CCATGTGAAATACGGCGAATTTGAGCTGGTTATCGGGATCGACTCAGGAGAGGCCTTGGAGGGTTACCTTCCCCCTAAAA
AGAGGAAACTGGCCGAGTCACATATTAAGGCCAATAAAACCAGGCTACTGGCTATGTGGCAGATGGCGGTTAATGGGATG
CATCCTGGGAAACTGTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT195093 WP_022649087.1 NZ_CP071023:3454040-3454366 [Enterobacter hormaechei]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT195093 NZ_CP094317:2017199-2017711 [Edwardsiella anguillarum]
ATGTTGAAAATTATTGATGTGGATGTGGTCGGCGACCATGTTATCGAGGTCGAGTTTAGCGACGGCTTCCGTGGTAGGGC
TGATTTAACCGCGCTGTTCAGCAAACCGCCCTTCTCTGCGATCGCCGACTTTAACCGCTTTTCCCTGACGGCCAGCGGCG
TGCTGAACTGGGGAGATGCCGAGCTTTCTGCCGATACGGTTAGGCGCATGAGCAAAGGCGCAGTGGTATCGGCATCCTCA
CGCTCACTCATGCCAGAAAATGTAGAAGCGATCCTCCGCCAGGCCACCTGGGAATCCATGAGCGAGGGGCGCCCGGATAT
TTTGCAAGCCGCGTTAAGGGGATACGCGGAGCAGCTGGGCCACGCGGACGTCATCAAAAGGGCCGGGATTGCCAGCCGCA
GCAGTGCATACAAAACGCTATCGCCATCAACGAACCCCAGCTTTAAATCACTGGCAAAGATCAGCGGCGCGATTTTGGCT
ATCGTGCGTGAAAATAACGCGCAGCACGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References