Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2279485..2280224 Replicon chromosome
Accession NZ_CP071023
Organism Enterobacter hormaechei strain RIVM_C012369

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag JQL72_RS10990 Protein ID WP_022648141.1
Coordinates 2279485..2279970 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag JQL72_RS10995 Protein ID WP_003857131.1
Coordinates 2279958..2280224 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL72_RS10960 2275534..2275794 + 261 WP_206215745.1 SDR family NAD(P)-dependent oxidoreductase -
JQL72_RS10970 2276852..2277523 + 672 WP_206215746.1 SDR family oxidoreductase -
JQL72_RS10975 2278172..2278453 + 282 Protein_2138 DUF4225 domain-containing protein -
JQL72_RS10980 2278428..2278757 - 330 WP_022648139.1 hypothetical protein -
JQL72_RS10985 2278890..2279459 + 570 WP_022648140.1 hypothetical protein -
JQL72_RS10990 2279485..2279970 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
JQL72_RS10995 2279958..2280224 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
JQL72_RS11000 2280288..2281217 - 930 WP_022648142.1 LysR family transcriptional regulator -
JQL72_RS11005 2281347..2282735 + 1389 WP_022648143.1 MFS transporter -
JQL72_RS11010 2282714..2283271 - 558 WP_022648144.1 OmpH family outer membrane protein -
JQL72_RS11015 2283392..2284528 - 1137 WP_022648145.1 type 1 fimbrial protein -
JQL72_RS11020 2284552..2285076 - 525 WP_087878309.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2255393..2283271 27878


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T195084 WP_022648141.1 NZ_CP071023:c2279970-2279485 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T195084 NZ_CP094315:c1168942-1168739 [Edwardsiella anguillarum]
ATGACCAAGATCGATTATCTAATGAAGCTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAACTAGAAATTTTTTATTCTGCTGCAGATCATCGACTAGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCGGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT195084 WP_003857131.1 NZ_CP071023:c2280224-2279958 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT195084 NZ_CP094315:c1169331-1168963 [Edwardsiella anguillarum]
ATGGATGAGTATACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAACCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCGTCGCACAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATACTGGATGATTATCTG
GATGAAACCTACGCCCTGTTTGGTGCCTATAGCGTCAGTGAAACGGCGCTCAGACACTGGCTGCGTACCAAACGCCGTGT
GGCATACTGCCTGGCGCATGAAAAGCGCAATGCGGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References