Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 253689..255312 Replicon plasmid pRIVM_C017238_1
Accession NZ_CP071022
Organism Enterobacter hormaechei strain RIVM_C017238

Toxin (Protein)


Gene name hipA Uniprot ID C1IUI3
Locus tag JQL79_RS23735 Protein ID WP_000088044.1
Coordinates 253689..255014 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A6M3PBR7
Locus tag JQL79_RS23740 Protein ID WP_012477377.1
Coordinates 255019..255312 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL79_RS23705 249675..250532 - 858 WP_000784387.1 HNH endonuclease -
JQL79_RS23710 250548..250856 - 309 WP_001224686.1 hypothetical protein -
JQL79_RS23715 251405..251830 - 426 WP_000278471.1 hypothetical protein -
JQL79_RS23720 252083..252898 - 816 WP_001641519.1 HNH endonuclease -
JQL79_RS23725 252911..253321 - 411 WP_000985909.1 hypothetical protein -
JQL79_RS23730 253422..253628 - 207 WP_000134171.1 hypothetical protein -
JQL79_RS23735 253689..255014 - 1326 WP_000088044.1 type II toxin-antitoxin system HipA family toxin Toxin
JQL79_RS23740 255019..255312 - 294 WP_012477377.1 helix-turn-helix transcriptional regulator Antitoxin
JQL79_RS23745 255713..257101 - 1389 WP_000083579.1 hypothetical protein -
JQL79_RS23750 257106..257603 - 498 WP_000340139.1 membrane protein -
JQL79_RS23755 257806..258462 - 657 WP_000462754.1 trypsin-like serine protease -
JQL79_RS23760 259121..259513 - 393 WP_000341066.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaACC-1 / msr(E) / mph(E) / mcr-9 / sul1 / qacE / ant(3'')-Ia / blaVIM-1 - 1..316079 316079


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50333.32 Da        Isoelectric Point: 6.5044

>T195081 WP_000088044.1 NZ_CP071022:c255014-253689 [Enterobacter hormaechei]
MSRKQQRLAIWMNGIKVGYWEKSKGVDSLQYLPDWSADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMRSSVENEWLCSVLLEQYGLPVARTQIAHFEDQKALVVERF
DRKWSGNGQWIIRLPQEDMCQALGISPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIVFWMMAATDGHAKNFS
ISIGPQGRYHLTPLYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T195081 NZ_CP094313:c3545642-3545226 [Edwardsiella anguillarum]
GTGGTCCTTTGGCGCTGTAACGTTCACGTCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCACGGCGCGCTGGTTTT
GGCGATCCTGCTGGCGCCCTGGCCGGAAAACTACAGCGCATTCTGGCTGGTTCTGCTGGTGGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGTCGGATTGCGCGTAACCGCGGTGAGCTGCAGCTGCTGACGCCGCAGGTGTGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGGCGCCCCTGGGTTAGCGATCTGGGGGCGCTGCTGATTCTGCAGAGTACCCATGGTGTACCGTG
CCGCCGCCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGAGAAGAGTGGGGGCAGCTGCGCCGCGCGCTGCTCGATACGG
GCGACGATCGCGCATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10860.30 Da        Isoelectric Point: 10.3134

>AT195081 WP_012477377.1 NZ_CP071022:c255312-255019 [Enterobacter hormaechei]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSTTASSEGK
QTEEMLKSNSPARQEKW

Download         Length: 294 bp

>AT195081 NZ_CP094313:c3545889-3545623 [Edwardsiella anguillarum]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGCGAGCTGGATATCGCGATTATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGCCTGCTGGCCTGCGACGATCCTGAGC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGACGACGCTGATCTGGCCCGTATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGTCCTTTGGCGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S1XXW1

Antitoxin

Source ID Structure
AlphaFold DB A0A6M3PBR7

References