Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3827270..3828051 Replicon chromosome
Accession NZ_CP071021
Organism Enterobacter hormaechei strain RIVM_C017238

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A431SHU0
Locus tag JQL79_RS18225 Protein ID WP_022649378.1
Coordinates 3827270..3827761 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3S0FY21
Locus tag JQL79_RS18230 Protein ID WP_022649379.1
Coordinates 3827758..3828051 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL79_RS18210 3822550..3823002 - 453 WP_022649375.1 hypothetical protein -
JQL79_RS18215 3823517..3825427 + 1911 WP_022649376.1 hypothetical protein -
JQL79_RS18220 3825424..3827118 + 1695 WP_022649377.1 hypothetical protein -
JQL79_RS18225 3827270..3827761 - 492 WP_022649378.1 GNAT family N-acetyltransferase Toxin
JQL79_RS18230 3827758..3828051 - 294 WP_022649379.1 DUF1778 domain-containing protein Antitoxin
JQL79_RS18235 3828153..3829946 - 1794 WP_022649380.1 hybrid sensor histidine kinase/response regulator -
JQL79_RS18240 3829943..3830575 - 633 WP_022649381.1 response regulator transcription factor -
JQL79_RS18245 3830751..3831065 + 315 WP_003862457.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3822550..3831065 8515


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(83-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17469.36 Da        Isoelectric Point: 8.1405

>T195079 WP_022649378.1 NZ_CP071021:c3827761-3827270 [Enterobacter hormaechei]
MISAPVPLRAGHILTPFCCGVDSMDNWLKQRAMKNQASGASRTFVCCGGDSNVLAYYALASSAVTTNTVPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAESIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMVTLGDLV
ASI

Download         Length: 492 bp

>T195079 NZ_CP094313:c1901824-1901543 [Edwardsiella anguillarum]
ATGACCTATAAACTGAGCTTTGAAAAGCGAGCCCTGAAAGAGTGGAAAAAACTGGCGCCGCCGATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTGGAAAACCCACATGTTCCAGCAGCACGCTTAAGTGGGCGCGCTAACCGTTATAAAATAA
AATTACGCTCTTCCGGTTACCGGTTAGTTTATGAAGTCAACGATAGCGAAATTATCCTGCTGGTGATCGCGATCGGTAAA
CGGGCCGATAACGAGGTGTACCAAGCGGCAGACAGTCGTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10959.58 Da        Isoelectric Point: 8.6351

>AT195079 WP_022649379.1 NZ_CP071021:c3828051-3827758 [Enterobacter hormaechei]
MPAANTMAVKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLTRLDQAPAPN
AALRKTMQTLAPWEQEK

Download         Length: 294 bp

>AT195079 NZ_CP094313:c1902065-1901814 [Edwardsiella anguillarum]
ATGGCATACCAAATTCTCACGACCACCGCCGCCAGCATTACCGACCTGAAACGCAATCCAATGGGTACCATTGCTGAAGG
TGACGGCAATGCCGTAGCAATCTTAAACCGCAATGAGCCGGCCTTTTACTGCGTTCCACCGGAACTCTACGCTTACTATC
TGGAGCTGGCTGAAGATGCGGCACTTAATCGTATCGCCGATGAGCGTCTGGAGGACGCTGAGTTTGTCAGCGTAAATATC
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SHU0

Antitoxin

Source ID Structure
AlphaFold DB A0A3S0FY21

References