Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3734332..3734989 Replicon chromosome
Accession NZ_CP071021
Organism Enterobacter hormaechei strain RIVM_C017238

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag JQL79_RS17745 Protein ID WP_022649305.1
Coordinates 3734332..3734742 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag JQL79_RS17750 Protein ID WP_003863437.1
Coordinates 3734723..3734989 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL79_RS17725 3730330..3732063 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
JQL79_RS17730 3732069..3732782 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JQL79_RS17735 3732811..3733707 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
JQL79_RS17740 3733809..3734330 + 522 WP_015571793.1 flavodoxin FldB -
JQL79_RS17745 3734332..3734742 - 411 WP_022649305.1 protein YgfX Toxin
JQL79_RS17750 3734723..3734989 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
JQL79_RS17755 3735284..3736264 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
JQL79_RS17760 3736788..3737447 - 660 WP_022649307.1 hemolysin III family protein -
JQL79_RS17765 3737714..3738445 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T195078 WP_022649305.1 NZ_CP071021:c3734742-3734332 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T195078 NZ_CP094313:c1168946-1168743 [Edwardsiella anguillarum]
ATGACCAAGATCGATTATCTAATGAAGCTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAACTAGAAATTTTTTATTCTGCTGCAGATCATCGACTAGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCGGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT195078 WP_003863437.1 NZ_CP071021:c3734989-3734723 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT195078 NZ_CP094313:c1169335-1168967 [Edwardsiella anguillarum]
ATGGATGAGTATACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAACCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCGTCGCACAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATACTGGATGATTATCTG
GATGAAACCTACGCCCTGTTTGGTGCCTATAGCGTCAGTGAAACGGCGCTCAGACACTGGCTGCGTACCAAACGCCGTGT
GGCATACTGCCTGGCGCATGAAAAGCGCAATGCGGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References