Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3454041..3454780 Replicon chromosome
Accession NZ_CP071021
Organism Enterobacter hormaechei strain RIVM_C017238

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag JQL79_RS16395 Protein ID WP_022649088.1
Coordinates 3454400..3454780 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag JQL79_RS16390 Protein ID WP_022649087.1
Coordinates 3454041..3454367 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL79_RS16375 3449935..3452595 - 2661 WP_022649084.1 hypothetical protein -
JQL79_RS16380 3453129..3453548 + 420 Protein_3197 antirestriction protein -
JQL79_RS16385 3453563..3454030 + 468 WP_022649086.1 DNA repair protein RadC -
JQL79_RS16390 3454041..3454367 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JQL79_RS16395 3454400..3454780 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
JQL79_RS16400 3454777..3455004 + 228 WP_022649089.1 hypothetical protein -
JQL79_RS16405 3455396..3455689 + 294 WP_022649090.1 hypothetical protein -
JQL79_RS16410 3456033..3457349 - 1317 WP_206215736.1 amidase -
JQL79_RS16415 3457404..3458699 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3429709..3455689 25980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T195077 WP_022649088.1 NZ_CP071021:3454400-3454780 [Enterobacter hormaechei]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T195077 NZ_CP094312:c57023-56625 [Edwardsiella anguillarum]
ATGTTGAAATATATGCTGGACACCAACATTTGTATCTTCACTCTGAAAAATAGGCCCGCTCAAGTTCGAGATAAATTTAA
CCTGCACCATAATCAAATGTGCATCAGCTCGATTACCTTGATGGAGTTGATTTATGGTGCAGAAAAAAGCCAATCCCCAG
AGCATAATCTGGCAGTTATTGAAGGATTTATTGCTCGGTTGACCGTATTGAACTACGACGCTCCAGCAGCCGCCCACTCC
GGCCAACTTCGTGCTGAACAAGCCCGGCTGGGCCAACCGATTGGCCCTTATGATCAGATGATTGCCGGACATGCTCGTAG
CCAGGGATTGATCCTCGTCACCAATAACACGCGGGAATTTGCGCGTGTCTCCGGGCTGAGGATTGAAGACTGGGTATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT195077 WP_022649087.1 NZ_CP071021:3454041-3454367 [Enterobacter hormaechei]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT195077 NZ_CP094312:c57250-57023 [Edwardsiella anguillarum]
ATGGAAACAACCGTTTTTCTTAGTAATCGTAGCCAGGCGGTCAGATTGCCAAAGGCCGTTGCATTACCCAGTGATGTCAA
ACGGGTCGATATTGTTGCTGTTGGACGAACCCGCATTATTACGCCCGCAGGAGAGTCCTGGGATAGCTGGTTTGAGGGTG
AAGGCGTCAGTACGGATTTTATGGCTAGCAGAGAGCAGCCCAAGGGACAGGAACGAGAGGATTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References